Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

ACTION ALERT: Telling Your Chronic Pain Story Now is Important

Migraine, Fibromyalgia and ME/CFS

Daily Non-Negotiables for Life with Chronic Illness

Where Is Your Journey Taking You?

Cognition and Chronic Fatigue Syndrome (ME/CFS): Key Findings and Seminal Papers

Living with Purpose

An ME/CFS and FM Recovery Story

#MillionsMissing: A Day of Global Protest

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

 
Print Page
Email Article

WPI describes how Ampligen boosts NK cell activity in XMRV-positive CFS patients' cells

  [ 55 votes ]   [ 3 Comments ]
By Isabel Barao-Silvestre, et al. • www.ProHealth.com • May 7, 2010


Following is the abstract of a research paper by a team of University of Nevada/Whittemore Peterson Institute researchers. The paper will be presented May 9 to immunologists gathered in Baltimore at Immunology 2010™ by UN/WPI lead author Isabel Barao-Silvestre.

[Note: Degranulation is release of microbe-toxic molecules from granules found inside some immune cells, including Natural Killer cells.] ______________________________________

Characterization of the therapeutic increases in Natural Killer (NK) activity of xenotropic murine leukemia virus-related virus (XMRV)-positive chronic fatigue syndrome (CFS) patients effected by poly (I): poly (C12U) (Ampligen) – Source: May 9 Presentation, Immunology 2010™

Chronic Fatigue Syndrome (CFS) is a debilitating disease of unknown etiology that affects ~17 million people worldwide. Patients suffer persistent viral infections and may develop hematopoietic malignancies. The patients have reduced Natural Killer (NK) cell activities which could contribute to the diseases, and, if restored, potentially reduce symptoms.

We characterized the in vitro effects on NK cells of the interferon inducer poly (I): poly (C12U) (Ampligen) which in some CFS patients abates disease symptoms.

The 30 CFS patients were infected with the gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

We cultured their peripheral blood mononuclear cells with the drug for 24 hrs and monitor NK activity to K562 cells by flow cytometry, concurrently measuring degranulation by externalization of CD107a, and expression of Grz B and perforin.

Treatment markedly increased CD107a externalization in the NK cell population as indicated by 5-fold increases in CD107a-positive cell frequencies and 3-fold increases in their CD107a MFI, with slight positive shifts in intracellular Grz B and perforin.

In contrast, T cells showed little change in CD107a externalization.

Our results suggest that degranulation rates may be more affected than the levels of cytotoxic proteins, indicating a novel mechanism by which NK activity was affected by the drug.

The increase in degranulation per NK cell indicates a mechanism by which Ampligen treatment can improve NK cell function.

Source: Poster for May 9 presentation by Isabel Barao Silvestre at Immunology 2010™ in Baltimore, Maryland. Paper by Barao-Silvestre I, Marshall M, Hagen KS, Pfost MA, Strayer D, Peterson D, Hudig D, Mikovits JA. Whittemore Peterson Institute, Reno; University of Nevada, Reno, Nevada; Hemispherx Biopharma, Inc., Philadelphia, Pennsylvania, USA.




Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

What?
Posted by: Mya Symons
May 9, 2010
Could someone explain this so a person without medical training could understand this?
Reply Reply

Ampligen
Posted by: jmkinsey
May 13, 2010
Ampligen has been in the works for years now. When is it ever going to be available? Or is it? I guess I'm getting a little impatient with the lack of availablitly of a promising treatment for a disease that has ruined 23 years of my life.
Reply Reply

LDN works too
Posted by: DiamonDie
May 14, 2010
You can also boost NK cell function with low dose naltrexone, which costs a tiny fraction of Ampligen's price tag, is much safer, doesn't require intravenous administration and is already available.
Reply Reply


Post a Comment

 
Dr Axe Bone Broth Proteins

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map