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A comprehensive review of coanalgesics: non-narcotic drugs that may help pain management

  [ 17 votes ]   [ Discuss This Article ] • February 8, 2012

Coanalgesics for Chronic Pain Therapy: A Narrative Review
– Source: Postgraduate Medicine, Nov 2011

By Matthew J Bair, Tamara R Sanderson

[Note: To read the full text of this article free, click HERE. It is a clear, comprehensive guide to medication options and use that “may enhance the effects of opioid analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs), have independent analgesic activity in certain painful conditions, or counteract the adverse effects of some analgesics.”]

Chronic pain is inadequately treated in many patients, which has led clinicians and researchers to investigate new indications for existing medications with pain-relieving or adjuvant properties.

These medications are known as coanalgesics.

This review provides an evidence-based overview of select coanalgesics that are used in clinical practice for a variety of neuropathic and musculoskeletal pain disorders.

The coanalgesics include:

• Antidepressants,

• Anticonvulsants,

• Topical agents,

• Skeletal muscle relaxants,

• And antispasmodic agents.

An update on emergent treatments and uses is also presented.

The goals of this article are to:

• Highlight coanalgesic treatment options that are currently available for patients with chronic pain

• As well as provide guidelines for their use in clinical practice.

Source: Postgraduate Medicine, Nov 2011; 123(6). Bair MJ, Sanderson TR. DOI: 10.3810/pgm.2011.11.2504, by  Roudebush VA Center of Excellence on Implementing Evidence-Based Practice; Indiana University School of Medicine; Reiganstrief Institute, Indianapolis, Indiana, USA. [Email:]

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