by H Jojaji, et al.
June 22, 2009
[Note: H. pylori is a type of bacteria that is responsible for the majority of peptic ulcers - ulcers in the lining of the stomach or duodenum (beginning of the small intestine). Its spiral shape helps it burrow into the stomach’s protective lining.]
Background: Vitamin C in gastric juice and in vitro has been shown to inhibit the growth of Helicobacter pylori (H. pylori).
Aims: The purpose of this study was to investigate the effect of addition of vitamin C to eradication regimen on H. pylori eradication rate.
Patients: This randomized controlled clinical trial was conducted on 312 patients with H. pylori infection who had referred to the Taleghani Research Center of Gastroenterology and Liver Disease.
Methods: Patients were randomly divided into two groups. Group A patients (162 patients) received amoxicillin 1g and metronidazole 500mg b.i.d., bismuth 240mg b.i.d. and omeprazole 40mg q.i.d. in two divided doses. Patients in group B (150 patients) received the same regimen plus 500mg vitamin C per day. All patients received therapy for 2 weeks. Four weeks later all patients underwent urea breath test and results were compared.
Results: A total of 140 patients in group A and 141 in group B completed the study. On intention-to-treat analysis 48.8% of patients in group A in comparison to 78% in group B responded to eradication therapy and had negative urea breath test (p<0.0001).
Conclusion: Addition of vitamin C to H. pylori treatment regimen of amoxicillin, metronidazole and bismuth can significantly increase H. pylori eradication rate.
Source: Digestive and Liver Disease, Jun 1, 2009. PMID: 19493713, by Zojaji H, Talaie R, Mirsattari D, Haghazali M, Molaei M, Mohsenian N, Derakhshan F, Zali MR. Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [E-mail:
swt_f@yahoo.com]
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