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2 of 12 CFS patients positive for XMRV/MLV sequences: Italian study

  [ 12 votes ]   [ Discuss This Article ] • August 1, 2012

Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome
- Source: New Microbiologica, July 2012

By Stefania Paolucci, Fausto Baldanti, et al.

[Note: The full text of this article is available free at Dr. Baldanti's email is provided there and in the source info below.]

XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences.

• Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences.

• In contrast, 40 selected control subjects were negative.

• CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences.

These findings:

• Do not confirm the high frequency of MLV-related viruses infection in CFS patients,

• But also contrast the widespread laboratory contamination previously suggested.

Source: New Microbiologica, July 2012;35, 341-344. By Paolucci S, Piralla A, Zenello C, Minoli L, Baldanti F. Virologia Molecolare, Virologia e Microbiologia, Clinica Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. [Email:]

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