Association of Active Human Herpesvirus-6, -7 and Parvovirus B19 Infection with Clinical Outcomes in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
- Source: Advances in Virology, Aug 13, 2012
By Svetlana Chapenko, et al.
[Note: The full text of this article can be found at http://www.hindawi.com/journals/av/2012/205085/]
Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated.
108 ME/CFS patients and 90 practically healthy persons were enrolled in the study.
Viral genomic sequences were detected by PCR, virus-specific antibodies and cytokine levels - by ELISA, HHV-6 variants - by restriction analysis.
Active viral infection including concurrent infection was found in 64.8% (70/108) of patients and in 13.3% (12/90) of practically healthy persons.
Increase in peripheral blood leukocyte DNA HHV-6 load as well as in proinflammatory cytokines' levels was detected in patients during active viral infection.
• Definite relationship was observed between:
- Active beta-herpesvirus [HHV-6 and HHV-7] infection and subfebrility [temp slightly above normal], lymphadenopathy [lymph node swelling] and malaise after exertion,
- And between active B19 infection and multi-joint pain.
• Neuropsychological disturbances were detected in all patients.
• The manifestation of symptoms was of more frequent occurrence in patients with concurrent infection.
The high rate of active HHV-6, HHV-7 and B19 infection / coinfection with the simultaneous increase in plasma proinflammatory cytokines' level as well as the association between active viral infection and distinctive types of clinical symptoms shows necessity of simultaneous study of these viral infections for identification of possible subsets of ME/CFS.
Source: Advances in Virology, Aug 13, 2012. doi:10.1155/2012/205085, by Chapenko S, Krumina A, Logina I, Rasa S, Chirstjakovs M, Sultanova A, Viksna L, Murovska M. August Kirchenstein Institute of Microbiology and Virology & Departments of Infectology and Dermatology and Neurology and Neurosurgery, Riga Stradins University, Riga, Latvia.