LANDMARK REPORT on ME/CFS Mitochondrial Dysfunction Protocol by Myhill et al.
November 28, 2012
"These patients do not suffer from hypochondria - the problem is mitochondria."
Ed Note: To read Dr. Myhill's Nov 28 press release explaining the meaning of this revolutionary research in lay terms, see "Dr. Myhill's Paradigm-Changing ME/CFS Mitochondrial Test & Treatment Results."
Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – a clinical audit
- Source: International Journal of Clinical and Experimental Medicine, Jan 2013 (online Nov 20, 2012)
By Sarah Myhill, Norman E Booth, John McLaren-Howard
[Note: read the full text of this free-access report at http://www.ijcem.com/files/IJCEM1207003.pdf. Two key findings are that: 1) mitochondrial function tests “clearly demonstrate that patients have serious biochemical pathology,” which was “invariably present” in the severely affected patients they tested; and 2) a mitochondrial-support regimen including several standard nutrients, plus other nutrients tailored to deficiencies shown in individual ATP function test results, supported an average 44% increase in mitochondrial energy score - with some patients improving much more.]
We report on an audit of 138 ME/CFS patients who attended a private practice and took the ATP Profile biomedical test.
The results revealed that all of these patients had measureable mitochondrial dysfunction.
A basic treatment regime, based on:
1) Eating the evolutionary correct stone-age diet,
2) Ensuring optimum hours of good quality sleep,
3) Taking a standard package of nutritional supplements [Acetyl L-carnitine, D-ribose, CoQ10, magnesium sulfate, and niacinamide (vitamin B-3), as outlined on page 40 of Dr. Myhill's downloadable book, Diagnosing and Treating Chronic Fatigue Syndrome (CFS)], and
4) Getting the right balance between work and rest….
…was recommended for all patients.
Additions to the basic regime were tailored for each patient according to the results of the ATP Profile and additional nutritional tests and clues from the clinical history.
Mitochondrial function is typically impaired in two ways:
• Substrate or co-factor deficiency,
• And inhibition by chemicals, exogenous or endogenous.
For the former, additional nutrients are recommended where there is a deficiency, and for the latter, improvement of anti-oxidant status and selective chelation therapy or far-infrared saunas are appropriate.
We show case histories of nine patients who have taken the ATP Profile on three or four occasions, and a before-and-after treatment summary of the 34 patients who have had at least two ATP Profile tests separated by some months.
Finally, we summarize the results for the 30 patients who followed all aspects of the treatment regime and compare them with the 4 patients who were lax on two or more aspects of the treatment regime.
All patients who followed the treatment regime improved in mitochondrial function by on average a factor of 4.
Source: International Journal of Clinical and Experimental Medicine, 2013;6(1):1-15. Myhill S, Booth NE, McLaren-Howard J. Sarah Myhill Ltd, Llangunllo, Powys UK; Department of Physics and Mansfield College, University of Oxford, Oxford UK; Acumen, Tiverton, Devon UK. [E-mail: Norman Booth firstname.lastname@example.org]
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