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‘Early’ oxidative stress damage in ME/CFS patients ages 15 to 45

  [ 4 votes ]   [ 2 Comments ] • December 4, 2012

Lipid and protein oxidation in female patients with chronic fatigue syndrome
- Source: Archives of Medical Science, Nov 9, 2012

By Slavica Tomic, Daniela Maric, et al.

[Note: the free full text of this paper reporting evidence of cell damage caused by oxidative stress in CFS patients in “an otherwise low-risk group,” ages 15 to 45, can be found HERE. A series of studies suggest that CFS may be caused in part by oxidative stress, according to Benjamin H Natelson, MD, a leading fatigue researcher now recruiting for a study of its possible impact on brain chemicals in CFS.]

Introduction: Chronic fatigue syndrome (CFS) is a widely recognized problem, characterized by prolonged, debilitating fatigue and a characteristic group of accompanying symptoms, that occurs four times more frequently in women than in men. The aim of the study was to determine the existence of oxidative stress and its possible consequences in female patients with CFS.

Material and methods: Twenty-four women aged 15-45 who fulfilled the diagnostic criteria for CFS with no comorbidities were recruited and were age matched to a control group of 19 healthy women.

After conducting the routine laboratory tests, levels of the lipid oxidation product malondialdehyde (MDA) and protein oxidation protein carbonyl (CO) were determined.

Results: The CFS group had higher levels of triglycerides (p = 0.03), MDA (p = 0.03) and CO (p = 0.002) and lower levels of HDL cholesterol (p = 0.001) than the control group.

There were no significant differences in the levels of total protein, total cholesterol or LDL cholesterol.


The CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins.

These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis.

Antioxidant treatment and life style changes are indicated for women with CFS, as well as closer observation in order to assess the degree of atherosclerosis.

Source: Archives of Medical Science, Nov 9, 2012. DOI:10.5114/aoms.2012.31620, by Tomic S, Brkic S, Maric D, Mikic AN. Clinic for Infectious Diseases and Clinic for Gynecology and Obstetrics, Clinical Center Vojvodina, Novi Sad, Serbia. [Email:]

Please Discuss This Article:   Post a Comment 

what type of supplements are they recommending for this issue?
Posted by: Ly45nn
Dec 6, 2012
what type of supplements are they recommending for this issue? What should I ask my doctor about this regarding tests?
Reply Reply

oxidative stress
Posted by: IanH
Dec 8, 2012
Oxidative stress induces low grade inflammation. (an immune inflammatory response). Since many people with ME have tested positive for mitochondrial dysfunction and glutathione depletion some correction of these problems can help. (look up these topics on PH, there is plenty of info. )In addition the lipid profile can be improved by supplementing with carnitine or acetyl carnitine. That is, if you can tolerate the carnitine.

One of the best low grade anti-inflammatory regimes is:
EPA/DHA 5:1 (omega 3 fatty acids in this ratio)
vitamin D3 5000IU
Magnesium chelate (citrate, glycinate, taurinate or other)


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