ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

One Gene, Many Disorders: Could One Gene Help Explain ME/CFS, FM, POTS, IBS, EDS, IBS and Others

The Cannabis Science Fibromyalgia Pain Patch: Fact or Fiction?

Brain Fog

Could Fibromyalgia Be A Low-Endorphin Disease?

Top 10 Benefits of Laughter for Fibromyalgia

The Difference Between Fibromyalgia Tender Points and Myofascial Trigger Points

SURVEY: Cognitive Impairment II

Chronic Christmas: Surviving the Holidays with a Chronic Illness

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Beginning Again: Living with the Ups and Downs of Life with Chronic Illness

 
Print Page
Email Article

Lower Levels of ATP and PCr Found in Muscles of Fibromyalgia Patients

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 7, 2013


[Note:  ATP stands for adenosine triphosphate, which is described as the energy currency of life.  Mitochondria are the energy producers in each cell and they supply this energy in the form of ATP.  PCr stands for phosphocreatinine, an organic compound found in muscle tissue that stores and provides energy for muscular contraction.]

Article:

Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients - A (31) P-MRS study.

– Source: European Journal of Pain, January 30, 2013

by G. Gerdle, et al.

Abstract:

BACKGROUND AND METHODS: Fibromyalgia (FMS) has a prevalence of approximately 2% in the population. Central alterations have been described in FMS, but there is not consensus with respect to the role of peripheral factors for the maintenance of FMS.

( 31) P Magnetic Resonance Spectroscopy ((31) P-MRS) has been used to investigate the metabolism of phosphagens in muscles of FMS patients, but the results in the literature are not in consensus. The aim was to investigate the quantitative content of phosphagens and pH in resting quadriceps muscle of patients with FMS (n?=?19) and in healthy controls (Controls; n?=?14) using (31) P-MRS. It was also investigated whether the concentrations of these substances correlated with measures of pain and/or physical capacity.

RESULTS:

  • Significantly lower concentrations of adenosine triphosphate (ATP) and phosphocreatinine (PCr; 28-29% lower) were found in FMS.

  • No significant group differences existed with respect to inorganic phosphate (Pi), Pi/PCr and pH.

  • The quadriceps muscle fat content was significantly higher in FMS than in Controls [FMS: 9.0?±?0.5% vs. Controls: 6.6?±?0.6%; (mean?±?standard error); P?=?0.005].

  • FMS had significantly lower hand and leg capacity according to specific physical test, but there were no group differences in body mass index, subjective activity level and in aerobic fitness.

  • In FMS, the specific physical capacity in the leg and the hand correlated positively with the concentrations of ATP and PCr; no significant correlations were found with pain intensities.

CONCLUSIONS: Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.


Source: European Journal of Pain, January 30, 2013. B. Gerdle, M.F. Forsgren, A. Bengtsson, O.D. Leinhard, B. Soren, A. Karlsson, V. Brandejsky, E. Lund, P. Lundberg.  Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Sweden; Pain and Rehabilitation Centre, UHL, Linköping, Sweden.





Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ Optimized Curcumin Longvida® B-12 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map