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CoQ10 Supplementation Improves Fibromyalgia Symptoms

  [ 7 votes ]   [ 2 Comments ] • March 10, 2013

Can Coenzyme Q10 improve clinical and molecular parameter in Fibromyalgia?
– Source: Antioxidants and Redox Signaling, March 4, 2013

By M.D. Cordero, et al.


Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction and coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology.

We have investigated the effect of CoQ10 supplementation. We carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300mg/day), in twenty FM patients. This study was registered with (ISRCTN 21164124).

  • An important clinical improvement was shown after CoQ10 vs placebo treatment showing a reduction of FIQ [Fibromyalgia Impact Questionnaire] (P<0.001),

  • and a most prominent reduction in pain (P<0.001), fatigue and morning tiredness (P?0.01) subscales from FIQ.

  • Furthermore, we observed an important reduction in pain visual scale (P<0.01)

  • and a reduction in tender points (P<0.01), including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis and AMPK gene expression levels, associated with phosphorilation of AMPK activity.

These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM.

Antioxidants and Redox Signaling, March 4, 2013. By M.D. Cordero, E. Alcocer-Gómez, M. de Miguel, O. Culic, A.M. Carrión, J.M. Alvarez-Suarez, P. Bullon, M. Battino, A. Fernández-Rodríguez, J.A. Sánchez-Alcázar. Dpto. Citología e Histología Normal y Patológica, Facultad de Medicina. Universidad de Sevilla, 41009 Sevilla-Spain, Avda. Sánchez-Pizjuán s/n, Sevilla, Spain, 41009, +34 95 4551797 , +34 95 4551799;

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Article Comments Post a Comment

Posted by: IanH
Mar 10, 2013
they used ubiquinone.

This is a great study showing how CoQ10 is as good as or better than any other parmaceutical prescribed for FM.

In our clinic we always use CoQ10 for FM. Working up to 200mg twice daily for three months then decline to 200mg daily thereafter.

When combined with VitB12, Magnesium, MTHF, Creatine Phos and ribose you do get a good result with most people.
Reply Reply

COQ10 dosage
Posted by: Diegolady
Mar 14, 2013
The article doesn't state what dosage they used in the study. I have used COQ10, but never know what dosage to use. Now I will go with the 200 mg daily. Thanks.
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