ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Rare But Potentially Serious Side Effect of Duloxetine (Cymbalta)

Fibromyalgia Has Central Nervous System Origins

VIDEO: Morgan Freeman Relies on Marijuana to Relieve Fibromyalgia Pain

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Heroes Amidst the Daily Grind of Chronic Illness

Dr. Pridgen on Doses, Fixing Broken Bodies and Why the Next Fibromyalgia Trials Will Be Better

Looking After Yourself Isn’t Selfish

Making Sense of Fibromyalgia for Awareness Day

Light – not pain-killing drugs – used to activate brain’s opioid receptors

 
Print Page
Email Article

Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine

  [ Not Yet Rated ]   [ Discuss This Article ]
By K. Tokizane et al. • www.ProHealth.com • April 11, 2013


Editor's Note: VGF is increased after injury and under conditions of chronic pain and inflammation. Because VGF is found abundantly in the limbic system, it plays a role in regulating metabolism, energy homeostasis, and appetite. The term "cryptogenic" means the cause is unknown. 

~Source: Mol Cell Endocrinol. Mar 26, 2013. 

By K. Tokizane et al.

Abstract

Prolonged exposure to stress elicits profound effects on homeostasis that may lead to cryptogenic disorders such as chronic fatigue syndrome.

To investigate the pathophysiology associated with the syndrome, we used a rat continuous stress (CS) model where the pituitary represents one of the most affected organs. Here we found that mRNA for VGF (non-acronymic), a member of the granin family, was induced specifically in the intermediate lobe (IL).

This was matched by a concomitant increase at the peptide/protein level assessed by C-terminal antibody. Furthermore, the upregulation of VGF was confirmed by immunohistochemistry in a subset of melanotrophs.

VGF expression was altered in the IL of rats receiving the dopamine D2 receptor agonist bromocriptine or the antagonist sulpiride. In vitro, dopamine dose-dependently decreased the mRNA levels in cultured melanotrophs.

These findings suggest that VGF expression under CS is negatively regulated by dopaminergic neurons projecting from the hypothalamus.

Source: Mol Cell Endocrinol. 2013 Mar 26. pii: S0303-7207(13)00108-1. doi: 10.1016/j.mce.2013.03.012. [Epub ahead of print]. Tokizane K, Konishi H, Yasui M, Ogawa T, Sasaki K, Minamino N, Kiyama H., Department of Functional Anatomy and Neuroscience, Nagoya University, Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing