Activate Now
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Do You Have These Fibromyalgia Symptoms of Systemic Dysfunction?

Fibromyalgia Is Finally Recognized as an Official Diagnosis!

Meet Devin Starlanyl: Fibromyalgia and Chronic Myofascial Pain Expert

The Fibromyalgia – Negativity Connection

Which Infection Causes CFS & Fibromyalgia?

Simplifying Nutritional Support in CFS & Fibromyalgia

Need Help with Pain Management? There's an App for That

6 Reasons Why Trigger Point Injections Aren't Helping Your Fibromyalgia

Exercise: Friend or Foe in Fibromyalgia?

How Multiple Chronic Illnesses Shaped One Woman Into a Patient Advocate

Print Page
Email Article

Fibromyalgia Drug Savella May Also Help Prevent Migraines

  [ 4 votes ]   [ 1 Comment ] • October 25, 2013

Editor's Comment:  Savella (milnacipran), an antidepressant, was the third drug to receive FDA approval for the treatment of fibromyalgia.  In this pilot study, researchers tested the effectiveness of milnacipran for reducing the frequency of episodic or chronic migraines.  Since a significant number of people with fibromyalgia also have migraines, a drug that could do double duty would be a plus. 

A prospective, open-label study of milnacipran in the prevention of headache in patients with episodic or chronic migraine.

By Emily Rubenstein Engel, David Kudrow and Alan M. Rapoport


Migraine is a highly prevalent episodic and chronic neurological disorder that impacts otherwise healthy men and women in their most productive years. An anecdotal survey in our clinical practices suggested that milnacipran, a drug indicated for the treatment of fibromyalgia, reduced the incidence of headache in patients with migraine.

In this 3-month, open-label, pilot study, 38 patients diagnosed with episodic migraine and 7 patients with chronic migraine maintained headache diaries to assess the effectiveness and tolerability of milnacipran in headache prevention. After a 1-month period to obtain baseline data, milnacipran treatment was initiated and doses were titrated up to 100  mg/day over 1  month. Maintenance therapy continued for an additional 3  months. The primary efficacy end point was change from baseline in the number of all headache days during the last 28  days of maintenance therapy analyzed, using last observation carried forward (LOCF). Change from baseline in migraine days during the last month of the maintenance period using LOCF was a secondary end point.

Milnacipran 100  mg daily was associated with a significant reduction in headache (-4.2  days; P  <  0.001) and migraine frequency (-2.2  days; P  <  0.003). The adverse event profile was consistent with prior reports of milnacipran for the treatment of other conditions. However, compared with the recommended protocol, a more gradual increase in milnacipran dose was required to improve tolerability for some patients.

The robust efficacy signal found in this study strongly suggests that a double-blind, placebo-controlled trial of milnacipran in migraine and chronic headache is warranted.

Source: Neurological Sciences, September 2013. By Emily Rubenstein Engel, David Kudrow and Alan M. Rapoport.  Dalessio Headache Center, Scripps Clinic, 10666 North Torrey Pines Rd. MS 313, La Jolla, CA, 92037, USA.

Please Discuss This Article:   Post a Comment 

Ginger helps HypoGal with Pain
Posted by: HypoGal
Oct 28, 2013
I have tried numerous medications to stop the Fibro pain. Unfortunately, I have not found the correct combo. I have tried Savella but the medication was not successful for me.
I believe my Fibro is link to inflammation in my body. I also believe my Fibro is secondary. I was stricken with Fibro after I developed Sheehan's Syndrome.
I have been eating about a half cup of raw ginger daily. I have found that ginger has helped with my pain from Relapsing Polychondritis.
I hope Savella can help others with Fibro
Reply Reply
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements for Fibromyalgia Support

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion

Natural Remedies

Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing