ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Drug Combo in Pridgen Antiviral Fibromyalgia Trial Identified – Some Results Available

7 Fibromyalgia Seasonal Stress Strategies

Blunted Anti-Inflammatory Response to Exercise Increases Fibromyalgia Symptoms

Fibromyalgia Associated with Coronary Heart Disease

Happiness, Gratitude and Appreciation

Cytokine and Chemokine Profiles in Fibromyalgia, RA and Lupus: A Potentially Useful Tool in Differen...

FDA Approves Hysingla ER – Extended-Release Hydrocodone with Abuse-Deterrent Properties

5 Safety Tips for the Holidays for Persons Living with Fibromyalgia and Myofascial Pain Syndrome

Sense of Smell Impaired in Fibromyalgia Patients

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery

 
Print Page
Email Article

Chronic fatigue in adult survivors of childhood cancer: Associated symptoms, neuroendocrine markers and autonomic cardiovascular responses

  [ 1 vote ]   [ Discuss This Article ]
By Bernward Zeller et al. • www.ProHealth.com • December 20, 2013


By Bernward Zeller et al.

Purpose: Chronic fatigue (CF) is a common late effect after childhood cancer. Based upon findings among patients with the chronic fatigue syndrome (CFS), this study explored symptoms, neuroendocrine markers and autonomic cardiovascular responses associated with CFS in childhood cancer survivors.

Methods: Long-term survivors of childhood lymphoma and acute lymphoblastic leukemia reporting CF were compared to survivors without CF. Data included patient-reported outcomes, clinical examination, head-up tilt test (HUT) and neuroendocrine markers in blood and urine.

Results: Of 102 included survivors, 15 were excluded from comparative analyses due to significant comorbidity or pregnancy. Of the remaining 87 participants (median age 33.0 years, follow-up time 25.2 years), 35 had CF and 52 did not have CF. Compared to non-CF controls, CF cases reported significantly (p<.01) higher frequency of symptoms typical of the chronic fatigue syndrome (muscle and/or joint pain, feeling confused/disoriented) and symptoms of autonomic dysfunction (palpitations, feeling intermittently heat and cold, watery diarrhea). CF cases and controls did not differ regarding autonomic cardiovascular responses to orthostatic stress, but the CF group had lower levels of plasma ACTH (p=.002), and higher levels of urine norepinephrine (p=.017).

Conclusions: Survivors with CF reported a high symptom-burden compared to controls. There were few differences between the two groups regarding biomarkers, but slight alterations of the hypothalamus-pituitary-adrenal axis and sympathetic nervous activity were detected. CF in cancer survivors has features in common with the chronic fatigue syndrome, but further efforts are required to clarify the pathophysiology.

Source:Zeller,Bernward, MD, Ellen Ruud, MD, PhD, Jon Havard Loge, MD, PhD, Adriani Kanellopoulos, MD, Hanne Hamre, MD, Kristin Godang, BScd, Vegard Bruun Wyller, MD, PhD. Chronic fatigue in adult survivors of childhood cancer: Associated symptoms, neuroendocrine markers and autonomic cardiovascular responses. Psychosomatics, December 8, 2013.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
"It's Not Easy Being Green" - But It Is Healthy

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing