Article:
Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome
- Source: New Microbiologica, July 2012
By Stefania Paolucci, Fausto Baldanti, et al.
[Note: The full text of this article is available free at http://www.newmicrobiologica.org/PUB/allegati_pdf/2012/3/341.pdf. Dr. Baldanti's email is provided there and in the source info below.]
Abstract:
XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences.
• Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences.
• In contrast, 40 selected control subjects were negative.
• CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences.
These findings:
• Do not confirm the high frequency of MLV-related viruses infection in CFS patients,
• But also contrast the widespread laboratory contamination previously suggested.
Source: New Microbiologica, July 2012;35, 341-344. By Paolucci S, Piralla A, Zenello C, Minoli L, Baldanti F. Virologia Molecolare, Virologia e Microbiologia, Clinica Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. [Email: f.daldanti@smatteo.pv.it]
