ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

You Might Have Fibromyalgia if...

A Link Between Dental Amalgams, Fibromyalgia, ME/CFS and Other Chronic Illnesses

Gait Characteristics of Women with Fibromyalgia: a Premature Aging Pattern

The Pain Brain: Hippocampal Atrophy Found in Fibromyalgia

The Myth of a Perfect Drug for Fibromyalgia or ME/CFS: the NNT Dilemma

Somatosensory Cortex Linked to Increased Sensitivity to Touch in Fibromyalgia

Color Me M&M: The NIH P2P Report on Opioids and Fibromyalgianess

Your voice matters! New Survey from National Fibromyalgia & Chronic Pain Association (NFMCPA)

Reduced Volume of Hippocampus May Be Related to Cognitive Problems in Fibromyalgia

VIDEO: Fibromyalgia Fitness: Your Simple 5-Step Exercise Plan

 
Print Page
Email Article

Low vitamin D & EBV immune activity may be key to MS breakthrough within 2–3 years: German research

  [ 59 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 19, 2012


Article:
Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis
– Source: Journal of Neurology, Neurosurgery and Psychiatry, Aug 11, 2012

By Brenard F Decard, Andrew Chan, et al.

[Apparently pre-onset blood donations provided this insight, underscored by the finding that the MS patients' average vitamin D levels had dropped another 50% by the time of diagnosis.]

Abstract:
Objective:
Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of multiple sclerosis (MS).

We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 individuals before the first clinical manifestation of MS.

Patients and methods:

• 56 serum samples of 25 individuals who had donated blood prior to the first clinical MS manifestation (clinically isolated syndrome (CIS))

• Four male subjects, 21 female subjects,

• Mean age 31.5 years at time of pre-CIS blood sampling;

• Mean age at disease onset 33.4 years…

….were available, covering an interval of 7.3 years-2 months (mean 31.5 months) before CIS.

In 18 of 25 patients serum samples were also obtained after established diagnosis of MS.

Longitudinal age- and gender-matched healthy blood donors (four male subjects, 21 female subjects, 39 samples, mean age 32.5 years) served as controls.

Serum 25-OH-D was measured by isotope dilution-liquid chromatography-tandem mass spectrometry. 25-OH-D levels were deconvoluted using published seasonal coefficients from a German population.

Immunoglobulin G (IgG) against Epstein-Barr virus nuclear antigen-1 (EBNA1) were assessed using commercially available ELISA.

Results:

• Low 25-OH-D levels were observed during the 24-month pre-CIS interval (47.8 (32.5-77.2) nmol/l, median (IQR); healthy controls: 81.6 (57.7-98.5), p=0.004,

• However, still higher than after established diagnosis (24.5 (13.7-47.7), p<0 .0001) compared with controls).

• IgG against EBNA1 during the 36-month pre-CIS interval was increased (185.9 (91.2–460.0) IU/ml, median (IQR); healthy controls 63.7 (29.5–121.6), p=0.002).

Conclusions: Low vitamin D and remote EBV infection may be associated with clinical MS breakthrough within 2–3 years.

Source: Journal of Neurology, Neurosurgery and Psychiatry, Aug 11, 2012. PMID:22888143, by Décard BF, von Ahsen N, Grunwald T, Streit F, Stroet A, Niggemeier P, Schottstedt V, Riggert J, Gold R, Chan A.Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum; Department of Neurology, St. Josef-Hospital, and Department of Molecular and Medical Virology, Ruhr-University Bochum; Department of Clinical Chemistry, University Medical Center Göttingen; German Red Cross Blood Transfusion Service West, Central Laboratory, Hagen; Department of Transfusion Medicine, University of Göttingen, Germany. [E-mail: andrew.chan@rub.de]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing