ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

What does fibromyalgia feel like?

Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.

Fibromyalgia and Thyroid Resistance

ADHD (Attention Deficit Hyperactivity Disorder) May Be Common in Fibromyalgia

Be Your Own Researcher: Treat Chronic Pain as a Daily Experiment

Five Things You Should Never Say to a Person with Chronic Illness...And What To Say Instead

Fibromyalgia has a high prevalence and impact in cardiac failure patients.

You Can Use Mindfulness to Choose How to Live

The International Support Fibromyalgia Network (ISFN)

Journey to a Diagnosis

Print Page
Email Article

Beyond XMRV: Swedish Team Broadens Hunt for Pathogen Involvement in ME/CFS

  [ 57 votes ]   [ 1 Comment ] • September 26, 2012

On Sep 22, ME Research UK ( formally introduced a new study it is supporting at Uppsala University in Sweden. As described below, the study will be a broad-based 'hunt' for evidence of viral/bacterial involvement in ME/CFS, using cutting edge technologies. It picks up where Uppsala's earlier study ruling out XMRV involvement in ME/CFS left off, and is designed to inform a larger investigation focused on biomarker development.


Search for the Aetiology of ME/CFS. Development of a rational diagnostic system based on microbiological biomarkers


Prof. Jonas Blomberg and Colleagues


Clinical Microbiology, Uppsala Academic Hospital, Uppsala University, Uppsala, Sweden [text on the site is largely in Swedish]

Background and Aims

Traditionally, myalgic encephalomyelitis has been associated with “outbreaks” of an epidemic character (see the list here), such as the famous example in 1955 at the Royal Free Hospital, London (page 12 in the Acheson article [article by E.D. Acheson, published in 1959 by the American Journal of Medicine.])

Even today, around half of all ME/CFS patients – non-epidemic cases seen in clinics all over the developed world – report that their illness started with an acute, infectious-like episode.

So, it’s no surprise there has been some research interest in which infectious agents might be involved, either in causing the illness or in maintaining its severity.

The table below lists some of the main viruses or bacteria that have been implicated in ME/CFS at some time, though to date no single agent has been proved to be the “smoking gun” in a majority of cases.


Table: Viruses and Bacteria Implicated in ME/CFS

- Enteroviruses, including coxackievirus
- Epstein-Barr virus (EBV)
- Cytomegalovirus
- Human herpes virus 6
- Parvovirus B19

- Chlamydia pneumoniae
- Coxiella burnetii (Q-fever)
- Mycoplasma spp.
- Brucella spp
- Borrelia burgdorferi (Lyme disease)


Given the potential importance of the role of infection in the illness, the aim of this study by Swedish researchers is to “interrogate” exhaustively a group of ME/CFS patients for evidence of a specific persistent or past infection.

The team, headed by Prof. Jonas Blomberg at the University of Uppsala, Sweden, will hunt for nucleic acids from and antibodies (primarily immunoglobulin G) against microbes previously reported to occur in elevated amounts or increased frequency in ME/CFS patients.

Importantly, the researchers will use novel multiplex technology which allows one blood sample to be tested for a large number of different infectious agents at the same time.

The technique means that multiple pathogens are tested for simultaneously, which diminishes variation between assays and tests, and reduces assay time and costs.

• Part of the new project consists of a development phase, involving the refinement of a variation tolerant capture multiplex assay or VOCMA capable of probing for a large number of potentially relevant infectious agents.

• The major phase, however, involves deploying this multiplex technology to probe for nucleic acids (the identifying signatures of microbes) to around 15 infectious agents previously reported to be connected with ME/CFS.

The method is flexible: It can be adapted to include new microbes, and if some microbes do not yield useful information, they can be excluded. The agents investigated will include:

• RNA viruses (such as enteroviruses);

• Small DNA viruses (such as parvovirus);

• Large DNA viruses (such as EBV and herpes virus 6);

• And bacteria, including Staphylocci, Borrelia, Chlamydiae and Mycoplasma.

In addition, sensitive antibody tests will establish whether patients have ever been in contact with infectious agents.

The aim of ME Research UK’s support is to “pump prime” the project, which is part of a larger investigation by the Swedish group on the development of biomarkers in ME/CFS.

This is the second grant that we have awarded to Prof. Jonas Blomberg’s team. The first, funded in conjunction with the Irish ME Trust was a thorough investigation of the possible presence of XMRV in Swedish patients.

The results of this 18-month project (Elfaitouri et al, PLoS ONE, 2011) were that XMRV and related virus could not be detected by several different methods (virus isolation, PCR and serology) in white blood cells or plasma from Swedish patients with ME/CFS or fibromyalgia, or in blood sera from Swedish blood donors, using the sensitive PCR techniques specifically developed.

Despite these negative findings, which accorded with results from other research groups around the world, Prof. Blomberg was determined to continue the hunt for viruses and bacteria which might be involved in this serious illness.

As he says:

Given the range and scope of intriguing findings by separate research groups, the situation is ripe for creation of a set of biomarkers. Some might be proteins in cerebrospinal fluid or blood, some might be immunological, and some might be microbiological (nucleic acid and antimicrobial antibody) as our investigation using multiplex technology hopes to reveal.

Together with good clinical data (including neuroimaging), I think we have a chance of creating a robust set of criteria which can aid in the diagnosis and perhaps also reveal more about the origins of ME/CFS.”

- ME Research UK, Sep 22, 2012


* This information is reproduced with kind permission of ME Research UK ( ©2012 ME Research UK. Scottish Charitable Incorporated Organisation No. SC036942. All Rights Reserved. The organization's principal aim is to commission, fund and 'energise' high-quality (biomedical) investigation into the causes, consequences and treatment of ME/CFS.

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Fibro Freedom™

Article Comments Post a Comment

Virus component, immunity component ........
Posted by: JayAnne
Sep 29, 2012
I vote for the Epstien Barr virus at least being one of the culprits! I was given the diagnoses of CFS after the Epstien Barr virus was found in my blood in 1989. To this day, just a year ago Epstien Barr was still detected, as well through out the years since being diagnosed, high antibodies count resulting in various autoimmune reactions, one being Hashimoto's which is most offend found with CFS patients. I believe the viruses activate And sometimes stay dormant. But once the do reactivate themseselves it cause our immune system to go into over drive and attack our own body system and changes the DNR. I'm sure that the longer you suffer with this immune dysfunction diease the more damage to different organs it haves. I believe in this results different organs in different people. The pancreas as in type one diabetes, thyroid in the case of Hashimoto's, MS, Lupus, Arthritis, Rheumatoid arthritis etc. or all. That's why it's a difficult and frustrating diease because it may not be that they can pinpoint the CFS as being deadly but any one of the above comorbids diseases may. For example type one diabetes...we all know that having diabetes shortens your life span due to complications which could be one of any organ dysfunction that high blood sugars can damage. To name a few, kidney, eyes, heart, neurological, losing a limb etc.
The Medical Community just has to put all this factors together and get on with it!! Enough already!
Reply Reply
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map