ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Namenda (memantine): A Potential NEW Treatment for Fibromyalgia

Daytime Napping Linked to Increased Fibromyalgia Symptom Severity

Minimizing Fibromyalgia Symptoms: Valuable Lessons from Childhood

An Update on Drugs Used for Treating Fibromyalgia

Respiratory Sinus Arrhythmia and Its Association with Pain in Women with Fibromyalgia

SURVEY: What Triggered Your Illness?

An Evaluation of Selective Serotonin Reuptake Inhibitors for Fibromyalgia

Why I Became a Fibromyalgia Advocate

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

5 Tips for When Motivation Runs Out

 
Print Page
Email Article

Effects of curcumin on stem-like cells in human esophageal squamous carcinoma cell lines - Source: BMC Complementary and Alternative Medicine, Oct 24 2012

  [ 2 votes ]   [ Discuss This Article ]
By Taghreed Almanaa, et al. • www.ProHealth.com • November 27, 2012


[Note: You may read the full text of this article free HERE.]

Background:
Many cancers contain cell subpopulations that display characteristics of stem cells. Because these cancer stem cells (CSCs) appear to provide resistance to chemo-radiation therapy, development of therapeutic agents that target CSCs is essential.

Curcumin is a phytochemical agent that is currently used in clinical trials to test its effectiveness against cancer. However, the effect of curcumin on CSCs is not well established.

The current study evaluated curcumin-induced cell death in six cancer cell lines derived from human esophageal squamous cell carcinomas.

Moreover, these cell lines and the ones established from cells that survived curcumin treatments were characterized.

Methods:
Cell loss was assayed after TE-1, TE-8, KY-5, KY-10, YES-1, and YES-2 cells were exposed to 20-80 muM curcumin for 30 hrs. Cell lines surviving 40 or 60 muM curcumin were established from these six original lines. The stem cell markers aldehyde dehydrogenase-1A1 (ALDH1A1) and CD44 as well as NF-kappaB were used to compare CSC-like subpopulations within and among the original lines as well as the curcumin-surviving lines. YES-2 was tested for tumorsphere-forming capabilities. Finally, the surviving lines were treated with 40 and 60 muM curcumin to determine whether their sensitivity was different from the original lines.

Results:
The cell loss after curcumin treatment increased in a dose-dependent manner in all cell lines. [Larger doses, increased cancer cell destruction.]

The percentage of cells remaining after 60 muM curcumin treatment varied from 10.9% to 36.3% across the six lines. The cell lines were heterogeneous with respect to ALDH1A1, NF-kappaB and CD44 expression. KY-5 and YES-1 were the least sensitive and had the highest number of stem-like cells whereas TE-1 had the lowest.

The curcumin-surviving lines showed a significant loss in the high staining ALDH1A1 and CD44 cell populations. Tumorspheres formed from YES-2 but were small and rare in the YES-2 surviving line. The curcumin-surviving lines showed a small but significant decrease in sensitivity to curcumin when compared with the original lines.

Conclusion:
Our results suggest that curcumin not only eliminates cancer cells but also targets cancer stem cells.

Therefore, curcumin may be an effective compound for treating esophageal and possibly other cancers in which cancer stem cells can cause tumor recurrence.

Source: BMC Complementary and Alternative Medicine, Oct 24, 2012;12:195. DOI:10.1186/1472-6882-12-195. By Almanaa TN, Geusz ME, Jamasbi RJ. Departments of Biological Sciences and Public & Allied Health, Bowling Green State University, Bowling Green, Ohio, USA. [Email: taghrea@bgsu.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing