Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fibromyalgia: The body holding on to past trauma

10 Fast Facts: Fibromyalgia Is Real

Ten Tips to Simplify, Lower the Cost, and Optimize CFS and fibromyalgia Treatment

Sleep, oh sleep, where art thou? Could your fibromyalgia medications be causing insomnia?

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

How to Obtain Relief for Fibromyalgia - Part 1: Complementary and Alternative Therapies

3 Genetic Reset Methods Your Doctor Should Prescribe for Fibromyalgia

Keep Learning – Even From Bed!

Buying Drugs from Canada - A Good Choice for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?

VIDEO: Dear Healthy People: Fatigue

 
Print Page
Email Article

Defect in Immune Response Leads to Recurring Bladder Infections

  [ Not Yet Rated ]   [ Discuss This Article ]
www.ProHealth.com • February 20, 2013


Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection

– Source: Immunity, February 15, 2013

By Cheryl Y. Chan et al.

Highlights

  • MC-dependent immunosuppressive transcriptional program specific to the bladder
  • Local production of IL-10 results in suppressed humoral and cell-mediated responses
  • Multiple MC-deficient mouse models show tissue-specific immunosuppressive role of MC
  • Bladder is a site exhibiting an intrinsic degree of MC-maintained immune privilege

Summary: The lower urinary tract’s virtually inevitable exposure to external microbial pathogens warrants efficient tissue-specialized defenses to maintain sterility. The observation that the bladder can become chronically infected in combination with clinical observations that antibody responses after bladder infections are not detectable suggest defects in the formation of adaptive immunity and immunological memory. We have identified a broadly immunosuppressive transcriptional program specific to the bladder, but not the kidney, during infection of the urinary tract that is dependent on tissue-resident mast cells (MCs). This involves localized production of interleukin-10 and results in suppressed humoral and cell-mediated responses and bacterial persistence. Therefore, in addition to the previously described role of MCs orchestrating the early innate immunity during bladder infection, they subsequently play a tissue-specific immunosuppressive role. These findings may explain the prevalent recurrence of bladder infections and suggest the bladder as a site exhibiting an intrinsic degree of MC-maintained immune privilege.

Source: Immunity, 2013; DOI:10.1016/j.immuni.2012.10.019. Cheryl Y. Chan, Ashley L. St. John, Soman N. Abraham.





Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ FibroSleep™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map