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Study Confirms Decreases in Immune Function in CFS/ME Patients, Suggests Biomarker

  [ 62 votes ]   [ 2 Comments ] • February 21, 2013

Editor’s Note: Natural killer (NK) cells are part of our body’s innate immune system. Their primary  function is to reject tumor and virus infected cells. They do this by releasing granzyme and perforin, which are small protein granules that target cells to be destroyed. This process is called apoptosis or programmed cell death.

Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis

~Source: J Transl Med. 2012; 10: 88

By Ekua W. Brenu et al.


Background: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an etiologically unexplained disorder characterised by irregularities in various aspects of the immunological function. Presently, it is unknown whether these immunological changes remain consistent over time. This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56 bright CD16- and CD56 dim CD16+) and cytokines, over the course of a 12-month period in patients with CFS/ME.

Methods: The participants in the study comprised 65 (47.2 ± 11.5 years) CFS/ME participants and 21 (45.2 ±9.3 years) non-fatigued controls. Flow cytometry protocols were used to assess NK subsets and NK cytotoxic activity at various time points that included baseline (T1), 6 (T2) and 12 months (T3). Cytokine secretions were measured following mitogenic stimulation of peripheral blood mononuclear cells.

Results: NK cytotoxic activity was significantly decreased in the CFS/ME patients at T1, T2 and T3 compared to the non-fatigued group. Additionally, in comparison to the non-fatigued controls, the CFS/ME group had significantly lower numbers of CD56 bright CD16- NK cells at both T1 and T2. Interestingly, following mitogenic stimulation, cytokine secretion revealed significant increases in IL-10, IFN-gamma and TNF-alpha at T1 in the CFS/ME group. A significant decrease was observed at T2 in the CFS/ME group for IL-10 and IL-17A while at T3, IL-2 was increased in the CFS/ME group in comparison to the non-fatigued controls. Overall cytotoxic activity was significantly decreased at T3 compared to T1 and T2. CD56 bright CD16- NK cells were much lower at T2 compared to T1 and T3. IL-10 and IL-17A secretion was elevated at T2 in comparison to T1 and T3.

Conclusion: These results confirm decreases in immune function in CFS/ME patients, suggesting an increased susceptibility to viral and other infections. Furthermore, NK cytotoxic activity may be a suitable biomarker for diagnosing CFS/ME as it was consistently decreased during the course of the 12 months study

Source: J Transl Med. 2012; 10: 88 doi: 10.1186/1479-5876-10-88. Ekua W Brenu, Mieke L van Driel, Donald R Staines, Kevin J Ashton, Sharni L Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra B Ramos, and Sonya M Marshall-Gradisnik.


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Article Comments Post a Comment

Clear marker
Posted by: IanH
Feb 21, 2013
This set of measures is a definite marker for ME.

Particularly the lower numbers of CD56 bright CD16- NK cells at both T1 and T2. Since mitogenic stimulation increased IL-10, IFN-gamma and TNF-alpha at T1 and lower cytotoxic activity, you would definitely expect greater viral activity and infection, possibly of the endogenous viruses too. Then with the drop in Il-10 and IL-17a you would expect inflammatory reactions reinforced by the rise in IL-2.

This is the best picture we have had for ME/CFS.
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CFS/ME Study with Possible Biomarker
Posted by: Katwilm
Feb 28, 2013
I'm just here to comment on the 3 stars out of 5 from the 47 viewers that took the time to make a rating. I think the fact that someone is looking into this and finding a possible biomarker rates VERY highly in my book. I thank the authors of this study for trying to find ways to help those of us with CFS/ME. FIVE STARS !!
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