Activate Now
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Do You Have These Fibromyalgia Symptoms of Systemic Dysfunction?

Fibromyalgia – The Savella Story

Meet Devin Starlanyl: Fibromyalgia and Chronic Myofascial Pain Expert

Which Infection Causes CFS & Fibromyalgia?

The "Mind Diet" Reduces the Risk Of Alzheimer’s Dementia. Might It Also Help the Brain Fog Found Wit...

Need Help with Pain Management? There's an App for That

6 Reasons Why Trigger Point Injections Aren't Helping Your Fibromyalgia

Simplifying Nutritional Support in CFS & Fibromyalgia

How Multiple Chronic Illnesses Shaped One Woman Into a Patient Advocate

VIDEO: Fibromyalgia & Your Stress-Coping Savings Account

Print Page
Email Article

Shortness of Breath in ME/CFS May be Due to CNS Dysregulation

  [ 5 votes ]   [ Discuss This Article ] • March 5, 2013

Editor’s Comment: This study used the CDC “Fukuda” criteria to establish the two CFS cohorts. Although the Fukuda criteria do not require post-exertional malaise, the researchers found a positive correlation between shortness of breath (dyspnea), and “Exertional Exhaustion.” There was also a high occurrence of fibromyalgia (42% and 47%) in the two CFS groups. In the full study the authors suggest that the sensations of dyspnea, including lightheadedness and chest pain, may be due to central nervous system dysregulation, specifically, dysautonomia

Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-sectional Studies

~Source: Global Journal of Health Science; Vol. 5, No. 2; 2013

By Murugan Ravindran et al. 


Background: Chronic Fatigue Syndrome (CFS) subjects have many systemic complaints including shortness of breath. Dyspnea was compared in two CFS and control cohorts to characterize potential pathophysiological mechanisms.

Methods: Cohort 1 of 257 CFS and 456 control subjects were compared using the Medical Research Council chronic Dyspnea Scale (MRC Score; range 0–5). Cohort 2 of 106 CFS and 90 controls answered a Dyspnea Severity Score (range 0–20) adapted from the MRC Score. Subsets of both cohorts completed CFS Severity Scores, fatigue, quality of life, and systemic complaints questionnaires. Cohort 2 also responded to other Dyspnea, affective and anxiety instruments. A subset had pulmonary function and total lung capacity (TLC) measurements.

Results: MRC Scores were equivalent for females and males in Cohort 1 CFS (1.92 [1.72-2.16]; mean [95% confidence interval]) and controls (0.31 [0.23-0.39]; P < 0.0001 by 2-tailed, unpaired Student's t tests with Bonferroni corrections). Receiver-operator curves identified 2 as the threshold for positive MRC Scores in Cohort 1. This indicated 54% of CFS, but only 3% of controls, had significant Dyspnea. In Cohort 2, the threshold Dyspnea Severity Score of 4 indicated shortness of breath in 67% of CFS and 23% of these controls. Cohort 2 Dyspnea Scores were higher for CFS (7.80 [6.60-9.00]) than controls (2.40 [1.60-3.20]; P < 0.0001). CFS had significantly worse fatigue, other CFS defining criteria and quality of life compared to controls. Although CFS had worse depressive affect and anxiety scores, only the controls showed correlations with Dyspnea Score. Pulmonary function was normal in CFS, but Borg scores and sensations of chest pain and dizziness were significantly greater during testing than controls. TLC was normal except for 2 of 16 CFS who had hyperinflation. A general linear model of Cohort 2 CFS responses linked Dyspnea Scores with rapid heart rate, chest pain and dizziness.

Conclusions: Sensory hypersensitivity without airflow limitation contributed to Dyspnea in CFS. Correlates of Dyspnea in controls were distinct from CFS suggesting different mechanisms.

Source: Global Journal of Health Science; Vol. 5, No. 2; 2013. Murugan Ravindran, Oluwatoyin Adewuyi, Yin Zheng, Uyenphuong Le, Christian Timbol, Samantha Merck, Rania Esteitie, Michelle Cooney, Charles Read, James Baraniuk. Georgetown University, Washington DC, USA

The full article can be accessed HERE.

Please Discuss This Article:   Post a Comment 

[ Be the first to comment on this article ]

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements for Fibromyalgia Support

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion

Natural Remedies

Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Eating Fat is Good… Maybe… Could Be… Sometimes Eating Fat is Good… Maybe… Could Be… Sometimes
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing