ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Lessons of Myofascial Pain Syndrome and Fibromyalgia

Exercise Tests Suggest Autoimmunity Causes the Exertion Problems in Chronic Fatigue Syndrome, Fibrom...

Chronic Isolation Risk for Fibro - Part 1

30 low-cost fibromyalgia and chronic Lyme treatments

The 3 things to do in a flare up

Is Poor Sleep Pummeling the Immune System in ME/CFS and Fibromyalgia? A Vicious Circle Examined

Fibromyalgia – Do You Even Have It? The Brady Approach to FM

Not Just an "Ill Person" - Ways to expand your identity when you're chronically ill

VIDEO: The Best Foods for Fibromyalgia

Prejudice against Women Living with Chronic Pain

 
Print Page
Email Article

Pathomechanisms of Autoantibody Production against the Nervous System

  [ 2 votes ]   [ Discuss This Article ]
By K. Arimura • www.ProHealth.com • April 14, 2013


Editor's Comment: This study is the most recent addition to the body of evidence that infections may be precipitating factors in the later development of chronic inflammation and subsequent autoimmunity in the nervous system. In a previous study performed at Queen Mary, University of London, researchers found a similar link between Epstein-Barr virus and multiple sclerosis, another neuro-degenerative autoimmune disease.

~Source: Brain Nerve. April, 2013. [Article in Japanese]

By K. Arimura

Abstract

In immune-mediated neurological disorders, the production of autoantibodies against the nervous system occurs mainly because of impaired immune tolerance. In myasthenia gravis (MG), the thymus shows pathologic alterations, particularly in anti-AChR antibody-positive patients. Further, resection of the thymus induces a clinical recovery.

The MG thymus contains all the elements, including AChR antigens, AChR-specific T cells, and antigen-secreting B cells, that are required to initiate and sustain autoantibody production. Central tolerance, established by the repertoire selection of immature T lymphocytes in the thymus, is impaired in MG patients who are positive for anti-AChR antibodies.

Recent evidence suggests that chronic inflammation elicited by viral infection is important for the production of AChR antibodies. Antibodies against ganglioside are crucial for the diagnosis of Guillain-Barre syndrome (GBS). Molecular mimicry between the lipooligosaccharides of Camplylobacter jejuni and gangliosides of the peripheral nerve causes the production of antibodies. However, less than 1 in 1000 patients infected with C. jejuni develop GBS. This fact suggests that some host factors might influence the production of antibodies. A recent hypothesis suggests that transient impairment of peripheral tolerance due to infection may play a crucial role in GBS pathogenesis.

In summary, autoantibody production might correlate with the impairment of immune tolerance as well as with innate immunity.

Source: Brain Nerve. 2013 Apr;65(4):323-32. Arimura K. Okatsu Neurology and Rehabilitation Hospital.





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Fibro Freedom™ Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain? Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map