ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Where Fibromyalgia and Chronic Fatigue Syndrome Part Ways (and Where They Don't)

Gastrointestinal Problems in Fibromyalgia

Does Fibromyalgia Diet = Deprivation?

The 2013 Fibromyalgia Alternative Diagnostic Criteria: Interpretation for Patients and Providers

Abnormal Cerebral Blood Flow Affects Cognitive Function in Fibromyalgia

Accepting and Surviving Chronic Illness

Hypersensitivity to Non-Painful Events May be Part of Pathology in Fibromyalgia

Alzheimer's Drug May Benefit Fibromyalgia Patients

Nerves, Estrogen, Dr. Mikovits and Paradoxes: The INTiDYN Approach to Fibromyalgia and Chronic Fatig...

VIDEO: Healthy Eating and Fibromyalgia

 
Print Page
Email Article

Over-Dilation of Arterioles Causes Over-Sensitization of Nerves in People with Fibromyalgia

  [ 5 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 15, 2013


Editor's Comment:  In this study, researchers measured the blood flow in the palms (glabrous skin) of people with fibromyalgia and controls. They discovered that people with FM had more vasodilation in the tiny little arterioles (smaller than arteries) that connect to the tiny little venules (smaller than veins) that connect to each other through shunts. These shunts allow blood flowing from the heart to flow back to the heart. Simply put, the arterioles in people with FM are remaining too dilated, which the researchers say is causing the nerves to become overly sensitive.  The result is pain in the hands of people with FM. 

Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole-Venule Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue.

Abstract:

OBJECTIVE: To determine if peripheral neuropathology exists among the innervation of cutaneous arterioles and arteriole-venule shunts (AVS) in fibromyalgia (FM) patients.

SETTING: Cutaneous arterioles and AVS receive a convergence of vasoconstrictive sympathetic innervation, and vasodilatory small-fiber sensory innervation. Given our previous findings of peripheral pathologies in chronic pain conditions, we hypothesized that this vascular location may be a potential site of pathology and/or serotonergic and norepinephrine reuptake inhibitors (SNRI) drug action.

SUBJECTS:
Twenty-four female FM patients and nine female healthy control subjects were enrolled for study, with 14 additional female control subjects included from previous studies. AVS were identified in hypothenar skin biopsies from 18/24 FM patient and 14/23 control subjects.

METHODS:
Multimolecular immunocytochemistry to assess different types of cutaneous innervation in 3 mm skin biopsies from glabrous hypothenar and trapezius regions.

RESULTS:
AVS had significantly increased innervation among FM patients. The excessive innervation consisted of a greater proportion of vasodilatory sensory fibers, compared with vasoconstrictive sympathetic fibers. In contrast, sensory and sympathetic innervation to arterioles remained normal. Importantly, the sensory fibers express a2C receptors, indicating that the sympathetic innervation exerts an inhibitory modulation of sensory activity.

CONCLUSIONS:
The excessive sensory innervation to the glabrous skin AVS is a likely source of severe pain and tenderness in the hands of FM patients. Importantly, glabrous AVS regulate blood flow to the skin in humans for thermoregulation and to other tissues such as skeletal muscle during periods of increased metabolic demand. Therefore, blood flow dysregulation as a result of excessive innervation to AVS would likely contribute to the widespread deep pain and fatigue of FM. SNRI compounds may provide partial therapeutic benefit by enhancing the impact of sympathetically mediated inhibitory modulation of the excess sensory innervation.

Source: Pain Medicine, May 20, 2013. By Phillip J. Albrecht PhD, Quanzhi Hou MD PhD, Charles E. Argoff MD, James R. Storey MD, James P. Wymer MD PhD, and Frank L. Rice PhD. Integrated Tissue Dynamics, LLC, Rensselaer, New York, USA; Center for Neuropharmacology & Neuroscience, Albany Medical College, Albany, New York, USA.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamin B-12

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing