ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

What the Pain Scale Really Means

Rare But Potentially Serious Side Effect of Duloxetine (Cymbalta)

Fibromyalgia Has Central Nervous System Origins

VIDEO: Morgan Freeman Relies on Marijuana to Relieve Fibromyalgia Pain

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Heroes Amidst the Daily Grind of Chronic Illness

Dr. Pridgen on Doses, Fixing Broken Bodies and Why the Next Fibromyalgia Trials Will Be Better

Looking After Yourself Isn’t Selfish

Making Sense of Fibromyalgia for Awareness Day

 
Print Page
Email Article

Chronic fatigue syndrome from vagus nerve infection: A psychoneuroimmunological hypothesis

  [ 16 votes ]   [ Discuss This Article ]
By Michael B. VanElzakker • www.ProHealth.com • June 24, 2013


Editor's Comment: The vagus nerve (the 10th cranial nerve) is a very long nerve that wanders from the brain stem to the intestines. It is primarily responsible for receiving sensory input through ganglia (nerve bundles), which is then processed by the brain. Neurotransmitters released through vagus nerve stimulation are parasympathetic; they slow physiological responses. Heart rate and blood pressure drop, neurons in the brain fire less, and so on. For this reason, vagus nerve stimulation is used to control tachycardia (rapid heartbeat) and epilepsy. An overstimulated vagus nerve can cause vasovagal syncope (fainting). VanElzakker's hypothesis states that the symptoms of CFS are caused by infections in vagus nerve ganglia. As an explanation for the cause of this illness, his hypothesis is worth consideration. A vagus nerve infection would affect every organ in the body. It should be mentioned here that the autopsy of Sophia Mirza  found damage in 80% of her dorsal root ganglia, which, like vagal ganglia, are responsible for processing afferent nervous system signals. (Sophia Mirza's symptoms included hypersensitivity to noise, light and touch.) It is possible that CFS/ME subsets may correlate with damage caused by infections in different nervous system ganglia.

By Michael B. VanElzakker 

Abstract 

Chronic fatigue syndrome (CFS) is an often-debilitating condition of unknown origin. There is a general consensus among CFS researchers that the symptoms seem to reflect an ongoing immune response, perhaps due to viral infection. Thus, most CFS research has focused upon trying to uncover that putative immune system dysfunction or specific pathogenic agent. However, no single causative agent has been found.

In this speculative article, I describe a new hypothesis for the etiology of CFS: infection of the vagus nerve. When immune cells of otherwise healthy individuals detect any peripheral infection, they release proinflammatory cytokines. Chemoreceptors of the sensory vagus nerve detect these localized proinflammatory cytokines, and send a signal to the brain to initiate sickness behavior. Sickness behavior is an involuntary response that includes fatigue, fever, myalgia, depression, and other symptoms that overlap with CFS.

The vagus nerve infection hypothesis of CFS contends that CFS symptoms are a pathologically exaggerated version of normal sickness behavior that can occur when sensory vagal ganglia or paraganglia are themselves infected with any virus or bacteria. Drawing upon relevant findings from the neuropathic pain literature, I explain how pathogen-activated glial cells can bombard the sensory vagus nerve with proinflammatory cytokines and other neuroexcitatory substances, initiating an exaggerated and intractable sickness behavior signal.

According to this hypothesis, any pathogenic infection of the vagus nerve can cause CFS, which resolves the ongoing controversy about finding a single pathogen. The vagus nerve infection hypothesis offers testable hypotheses for researchers, animal models, and specific treatment strategies.

SourceMedical Hypotheses. 21 June 2013 (10.1016/j.mehy.2013.05.034). Michael B. VanElzakker 




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing