Activate Now
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Aromatherapy Diffusers For Fibromyalgia Support

Chronic Fatigue Syndrome, Fibromyalgia and Mitchondrial Disorders: A Comparison Plus the MitoQ Trial...

Dr. Teitelbaum's 3 Steps to Fibromyalgia Pain Relief - Part 1: Understanding Fibromyalgia Pain

An Interview with Ken McKim: Educating the public about chronic illness

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Milnacipran for pain in fibromyalgia in adults

Are All the "Feel-Good" Pathways Blocked in Fibromyalgia and Chronic Fatigue Syndrome?

5 Things I've Learned About Chronic Illness Through Mindfulness

SURVEY RESULTS: Has Your Illness Affected What You Eat?

Staying healthy from fibromyalgia is ongoing hard work

Print Page
Email Article

Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome

  [ 4 votes ]   [ 1 Comment ]
By K. C. Light et al. • • October 16, 2013

Editor's Comment: In this study, the researchers implicated a peptide named Diazepam Binding Inhibitor (DBI) as a source of fatigue in patients receiving androgen deprivation therapy for prostate cancer, and in patients with ME/CFS. DBI is a natural GABA-A inverse agonist, that is, it produces the opposite effects of anxiolytics (e.g. Valium). Subjects injected with synthetic DBI experience sweating, nausea, palpitations, tightness in the chest, restlessness and generalized anxiety. Certain steroids, among which is DHEA, the precursor to estrogen, bind to GABA-A receptors, producing effects similar to anxiolytics. Other hormones, such as pregnenolone, the precursor to progesterone, have effects similar to DBI. The implication of this study for ME/CFS patients is that increased DBI not only is related to heightened anxiety states (i.e. upregulated sympathetic activity), but to fatigue as well.

By K. C. Light et al.


BACKGROUND: Androgen deprivation therapy (ADT) often worsens fatigue in patients with prostate cancer, producing symptoms similar to chronic fatigue syndrome (CFS). Comparing expression (mRNA) of many fatigue-related genes in patients with ADT-treated prostate cancer versus with CFS versus healthy controls, and correlating mRNA with fatigue severity may clarify the differing pathways underlying fatigue in these conditions.

METHODS: Quantitative real-time PCR was performed on leukocytes from 30 fatigued, ADT-treated prostate cancer patients (PCF), 39 patients with CFS and 22 controls aged 40-79, together with ratings of fatigue and pain severity. 46 genes from these pathways were included: (1) adrenergic/monoamine/neuropeptides, (2) immune, (3) metabolite-detecting, (4) mitochondrial/energy, (5) transcription factors.

RESULTS: PCF patients showed higher expression than controls or CFS of 2 immune transcription genes (NR3C1 and TLR4), chemokine CXCR4, and mitochondrial gene SOD2. They showed lower expression of 2 vasodilation-related genes (ADRB2 and VIPR2), 2 cytokines (TNF and LTA), and 2 metabolite-detecting receptors (ASIC3 and P2RX7). CFS patients showed higher P2RX7 and lower HSPA2 versus controls and PCF. Correlations with fatigue severity were similar in PCF and CFS for only DBI, the GABA-A receptor modulator (r=-0.50, p<0.005 and r=-0.34, p<0.05). Purinergic P2RY1 was correlated only with PCF fatigue and pain severity (r=+0.43 and +0.59, p=0.025 and p=0.001).

CONCLUSIONS: PCF patients differed from controls and CFS in mean expression of 10 genes from all 5 pathways. Correlations with fatigue severity implicated DBI for both patient groups and P2RY1 for PCF only. These pathways may provide new targets for interventions to reduce fatigue.

Copyright © 2013 Elsevier Ltd. All rights reserved.

Source: Psychoneuroendocrinology. 2013 Sep 6. pii: S0306-4530(13)00297-7. doi: 10.1016/j.psyneuen.2013.08.008. [Epub ahead of print]. Light KC, Agarwal N, Iacob E, White AT, Kinney AY, Vanhaitsma TA, Aizad H, Hughen RW, Bateman L, Light AR.Department of Anesthesiology, University of Utah Health Sciences Center, Salt Lake City, UT, USA. Electronic address:

Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ Energy NADH™ 12.5mg Guaifenesin FA™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

Translation greatly appreciated
Posted by: sPeeDeeBee
Oct 21, 2013
Thanks indeed for the editor's commentary preceding the introduction to this paper. Not surprisingly, understanding a condition as central to core metabolism as CFS/ME seems to be is going to require integrating detailed knowledge across a broad spectrum of scientific disciplines--and their related jargons. As my father was wont to say, "It's tough telling the players without a scorecard."
Reply Reply
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Eating Fat is Good… Maybe… Could Be… Sometimes Eating Fat is Good… Maybe… Could Be… Sometimes
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing