ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Fibromyalgia Research Update from Integrated Tissue Dynamics

Sweet Tips for Fibromyalgia Success

VIDEO: Treating Fibromyalgia with Oxytocin

Fibromyalgia, Family and Friends: 8 Ways to Improve Relationships

Fibromyalgia and Disability Claims

The Brain Boosting and Fatigue Fighting B-12

Is Hyperparathyroidism Sometimes Misdiagnosed as Fibromyalgia?

Melatonin Regulates Inflammation Resolution in Fibromyalgia and Other Disorders

Pain Affects Brain Area Associated with Cognitive Function in Fibromyalgia Patients

Protecting Your Fibromyalgia Window of Well

 
Print Page
Email Article

Interstitial Cystitis may be considered a chronic inflammatory disease

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • November 1, 2013


Editor's Comment: Interstitial cystitis is a common comorbidity among patients with ME/CFS and fibromyalgia. Dr. Jay Goldstein observed that 20% of his patients experienced pain upon urination, while other physicians have placed that percentage even higher (up to 90%). For those who suffer from this condition, constant bladder pain can be just as disabling as any other symptom. 

Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome

Yuan-Hong Jiang et al.

Abstract

Objective: The etiology and pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS) are unclear. Chronic inflammation is considered the main pathology of IC/BPS. This study measured the serum c-reactive protein (CRP), nerve growth factor (NGF) and pro-inflammatory cytokine/chemokine interleukin (IL)-1?, IL-6, tumor necrosis factor (TNF)-?, and IL-8 expression in patients with IC/BPS to elucidate the involvement of systemic inflammation in IC/BPS.

Methods: Serum samples were collected from 30 IC/BPS patients and 26 control subjects. The concentrations of serum nerve growth factor (NGF), IL-1?, IL-6, TNF-?, and IL-8 were quantified using a bead-based, human serum adipokine panel kit. Serum C-reactive protein

(CRP) was also assessed. Differences of serum CRP, NGF, IL-1?, IL-6, TNF-?, and IL-8 levels between the IC/BPS patients and controls were compared, and correlations between CRP and pro-inflammatory cytokines and chemokine were also evaluated.

Results: The results showed that CRP level (p = 0.031), NGF (p = 0.015) and pro-inflammatory cytokines/chemokine IL-1?, IL-6, TNF-?, and IL-8 levels were significantly higher in the patients with IC/BPS than among controls (all p<0.001). Significant associations were observed between IL-1? and IL-8 (p<0.001), IL-6 and CRP (p = 0.01), IL-6 and IL-8 (p = 0.02), and IL-6 and TNF-? (p = 0.03).

Conclusion: Increased pro-inflammatory cytokines/chemokine (IL-1?, IL-6, TNF-?, and IL-8) expression in the sera of IC/BPS patients implies not only mast cell activation, but also that other inflammatory mediators play important roles in the pathogenesis of IC/BPS. Thus, for some patients, IC/BPS is considered a chronic inflammatory disease.

SourcePLoS ONE 8(10): e76779 doi:10.1371/journal.pone.0076779.Jiang Y-H, Peng C-H, Liu H-T, Kuo H-C (2013) Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome. 





Discuss This Article Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing