ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fibromyalgia and Thyroid Dysfunction

Crash and Flare Busters for ME/CFS and Fibromyalgia

Losing Brain Matter – the Fibromyalgia Way

Letter to My Chronic Illness

Surviving the Holidays with Chronic Fatigue Syndrome and Fibromyalgia. How Do You Do It?

Gray matter abnormalities associated with fibromyalgia: A meta-analysis of voxel-based morphometric ...

A 13-Weeks Mindfulness Based Pain Management Program Improves Psychological Distress in Patients wit...

Setting Goals When You Are Chronically Ill

The Surprising Magic of a Not-To-Do List

Top 8 Natural Recipes for Healthy Skin

 
Print Page
Email Article

How hormones and microbes drive the gender bias in autoimmune diseases

  [ 5 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 13, 2013


How hormones and microbes drive the gender bias in autoimmune diseases

Press ReleaseCell Press, via EurekAlert!, a service of AAAS.

Females can mount more powerful immune responses than males, but the flip side of this enhanced protection against infections is a greater risk for autoimmune disorders. Shedding light on the underlying causes of the gender bias in autoimmune diseases, a study published by Cell Press August 22nd in the journal Immunity reveals that certain gut microbes prevalent in males can help protect them against type 1 diabetes. The study demonstrates that these microbes cooperate with sex hormones to cause this gender bias and provides an important framework that could lead to better treatments.

"The gender bias in major autoimmune diseases is well known but not well understood," says senior study author Alexander Chervonsky of the University of Chicago. "By studying how microbes cooperate with hormones to affect the immune system, we can identify pathways that can be triggered artificially by drugs or manipulations of gut microbes to interfere with the course of autoimmunity."

Sex hormones are known to play an important role in the gender bias of autoimmune diseases. But studies have shown that environmental influences and other non-hormonal factors also make a difference. For instance, animals that lack gut microbes because they were raised in a germ-free environment do not show a pronounced gender bias in type 1 diabetes, which is generally considered to be an autoimmune disorder. Until now, it has not been clear how hormones and microbes work together to influence the gender bias in type 1 diabetes and other autoimmune diseases.

In the new study, Chervonsky and his team found that microbial communities in male and female mice became different once the mice reached puberty, whereas microbes in females and castrated males were more similar to each other. These results suggest that sex hormones contribute to gender-specific changes in microbial communities. When the researchers raised mice in a germ-free environment and then exposed them to different types of bacteria, they discovered that only certain microbes specifically protected males against type 1 diabetes.

Taken together, the findings suggest that hormones and microbes cooperate with each other to protect males against autoimmune diseases. "Our study has helped to establish the general principles of how hormones and microbes interact with the immune system, which is the first significant step to get to the stage of developing new therapies."

Citation: Leonid Yurkovetskiy, Michael Burrows, Aly A. Khan, Laura Graham, Pavel Volchkov, Lev Becker, Dionysios Antonopoulos, Yoshinori Umesaki, Alexander V. Chervonsky. Gender Bias in Autoimmunity Is Influenced by Microbiota. Immunity, 22 August 2013 DOI: 10.1016/j.immuni.2013.08.013




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® B-12 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Live Without Anxiety or Stress Live Without Anxiety or Stress
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Safely Burn Away Body Fat Safely Burn Away Body Fat

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map