Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Things Fibromyalgia Sufferers Need to Stop Doing

How to Cope When Others Don't Understand Your Illness

Melatonin Helps Fibromyalgia Pain: A Double-Blind Study

Super Bowl Champ Dominique Easley Tackles Fibromyalgia for His Sister

Update on the Genetics of Fibromyalgia

Potential Sleep-Related Treatment Targets for Fibromyalgia Identified

Neurogenic Neuroinflammation in Fibromyalgia and Complex Regional Pain Syndrome

Epigenetics, Fibromyalgia and You!

Getting a Great Night Sleep with Fibromyalgia - Even When You've Tried EVERYTHING!

SURVEY: Have You Been Misdiagnosed?

 
Print Page
Email Article

Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome

  [ 20 votes ]   [ Discuss This Article ]
By R.C. Vermeulen and I.W. Vermeulen van Eck • www.ProHealth.com • February 1, 2014


Editor's Comment: The 2-day CPET studies conducted by Staci Stevens and Christopher Snell at the Workwell Foundation, and by Betsy Keller at Ithaca College, have shown deficits in oxygen uptake in ME/CFS patients. This study examined data from 440 participants and concluded that these deficits were indicative of reduced mitochondrial function. "The low oxygen extraction during exercise was also reported in mitochondrial pathology, systemic lupus erythematosus, HIV, and myophosphorylase deficiency." Significantly, the researchers did not find an association between exercise intolerance and deconditioning in ME/CFS patients.
 
Note: You can read the full text of this study HERE.

By R.C. Vermeulen and I.W. Vermeulen van Eck 
 
Abstract
 
BACKGROUND: The insufficient metabolic adaptation to exercise in Chronic Fatigue Syndrome (CFS) is still being debated and poorly understood.
 
METHODS: We analysed the cardiopulmonary exercise tests of CFS patients, idiopathic chronic fatigue (CFI) patients and healthy visitors. Continuous non-invasive measurement of the cardiac output by Nexfin(R) (BMEYE B.V. Amsterdam, the Netherlands) was added to the cardiopulmonary exercise tests. The peak oxygen extraction by muscle cells and the increase of cardiac output relative to the increase of oxygen uptake (DeltaQ'/DeltaV'O2) were measured, calculated from the cardiac output and the oxygen uptake during incremental exercise.
 
RESULTS: The peak oxygen extraction by muscle cells was 10.83 +/- 2.80 ml/100ml in 178 CFS women, 11.62 +/- 2.90 ml/100ml in 172 CFI, and 13.45 +/- 2.72 ml/100ml in 11 healthy women (ANOVA: P=0.001), 13.66 +/- 3.31ml/100ml in 25 CFS men, 14.63 +/- 4.38 ml/100ml in 51 CFI, and 19.52 +/- 6.53 ml/100ml in 7 healthy men (ANOVA: P=0.008).The DeltaQ'/DeltaV'O2 was > 6 L/L (normal DeltaQ'/DeltaV'O2 [almost equal to] 5 L/L) in 70% of the patients and in 22% of the healthy group.
 
CONCLUSION: Low oxygen uptake by muscle cells causes exercise intolerance in a majority of CFS patients, indicating insufficient metabolic adaptation to incremental exercise. The high increase of the cardiac output relative to the increase of oxygen uptake argues against deconditioning as a cause for physical impairment in these patients.
 
Source: Vermeulen RC, Vermeulen van Eck IW. Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome. J Transl Med. 2014 Jan 23;12(1):20. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24456560



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing