ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Me

Eli Lilly Settles Cymbalta Withdrawal Lawsuits

Top Fibromyalgia Drug Tanks: Four Other Drugs On Way

A Genetic Panel for Fibromyalgia? The New Proove Genetic Test

Fibromyalgia Life Lessons - What You Need to Know.

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

Genes May Be Causing Neuroinflammation and Pain in Fibromyalgia

Pacing through the Perils of Fibromyalgia

3 Fibromyalgia Struggles I’m Glad I Had

The Psychosocial Disease – Has Fibromyalgia Been Captured by a Behavioral Paradigm?

Print Page
Email Article

Drug Class Review: Drugs for Fibromyalgia

  [ 59 votes ]   [ Discuss This Article ]
By Beth Smith, DO, et al. • • March 16, 2014

Note: You can read the entire review by clicking on the links in the Contents section HERE.

Editor's comment: This is the final report on a review of drugs used for the treatment of fibromyalgia conducted in 2011 as part of the Drug Effectiveness Review Project (DERP). DERP is a collaboration of public entities (Medicaid pharmacy programs, the Center for Evidence-based Policy and the Pacific Northwest Evidence-based Practice Center) who have joined together to produce systematic, evidence-based products of the comparative effectiveness and safety of drugs in many widely used drug classes, and to apply the findings to inform public policy and related activities in local settings.

Final Original Report

Structured Abstract:

Purpose: We compared the effectiveness and harms of tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, noradrenergic and specific serotonergic reuptake inhibitor, norepinephrine and dopamine reuptake inhibitor, serotonin receptor antagonist, antiepileptic drugs, and skeletal muscle relaxants in adults with fibromyalgia.
Data Sources: We searched Ovid MEDLINE®, the Cochrane Database of Systematic Reviews®, and the Cochrane Central Register of Controlled Trials® and Database of Abstracts of Reviews of Effects through October 2010. For additional data we also hand searched reference lists, US Food and Drug Administration medical and statistical reviews and dossiers submitted by pharmaceutical companies.

Review Methods: Study selection, data abstraction, validity assessment, grading the strength of the evidence, and data synthesis were all carried out according to standard Drug Effectiveness Review Project review methods.

Results and Conclusions: We found eligible studies of treatment for fibromyalgia with amitriptyline, nortriptyline, citalopram, fluoxetine, paroxetine, cyclobenzaprine, pregabalin, gabapentin, milnacipran, and duloxetine. We found no eligible studies with the other included drugs and no eligible studies of included interventions when used as adjunctive therapy.
  • Head-to-head trials were few, and provided low-strength evidence that short-term treatment with immediate-release paroxetine is superior to amitriptyline in reducing pain and sleep disturbance

  • and provided low-strength evidence there are no significant differences between amitriptyline as compared with cyclobenzaprine and nortriptyline.

  • Although there were some significant differences between drugs in overall adverse events, they did not produce any differences in withdrawals due to adverse events.

  • Additionally, based on indirect comparison meta-analysis, we found low evidence that duloxetine was superior to milnacipran on outcomes of pain, sleep disturbance, depressed mood, and health-related quality of life.

  • We found low evidence that both duloxetine and milnacipran were superior to pregabalin on improvement in depressed mood, whereas pregabalin was superior to milnacipran on improvement in sleep disturbance.

  • Amitriptyline was similar to duloxetine, milnacipran, and pregabalin on outcomes of pain and fatigue, with insufficient data on the other outcomes.

  • Although there were some significant differences between duloxetine, milnacipran, and pregabalin in specific adverse events, they did not produce any differences in overall withdrawals, overall adverse events, and withdrawals due to adverse events.

  • For the remaining drugs, there was only evidence of significant improvements in pain over placebo in 1 trial for gabapentin, in 1 of 3 trials for cyclobenzaprine, and in 1 trial of fluoxetine.

  • But, no conclusions can be drawn about comparative effectiveness or harms among these drugs because the numbers of trials/patients in placebo-controlled trials were too few to provide meaningful results in indirect comparisons.

  • Duloxetine was not effective on pain reduction in male, nonwhite, and older patients based on a small sample size that was underpowered to detect a difference.

  • Compared with placebo, duloxetine, fluoxetine, controlled-release paroxetine, and pregabalin significantly improved fibromyalgia symptoms regardless of baseline depression but milnacipran was only effective in nondepressed patients.

  • Controlled -release paroxetine and pregabalin significantly improved fibromyalgia symptoms regardless of baseline anxiety.

Source: Drug Effectiveness Review Project, April 2011. By Beth Smith, DO, Kim Peterson, MS, Rochelle Fu, PhD, Marian McDonagh, PharmD, and Sujata Thakurta, MPA:HA. Portland (OR): Oregon Health & Science University.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Fibro Freedom™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map