ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The best sleeping positions for pain

VIDEO: Anxiety: 11 Things We Want You to Understand

Chronic Pain, Loneliness, Depression and Suicide

Is There a GERD—Fibro Connection?

Beyond pain in fibromyalgia: insights into the symptom of fatigue.

Things to Do When You're Mostly Housebound

Is a Good Night's Sleep at the Top of Your Wishlist?

Stair negotiation in women with fibromyalgia: A descriptive correlational study.

Could a Diet Reduce the Pain in Fibromyalgia? A FODMAPS Study Suggests Yes

Tying the Brain and Body Together in Fibromyalgia?

 
Print Page
Email Article

Able to Detect Even Precancerous Colon Polyps Noninvasively, Mayo’s DNA Stool Test Looks Like a Winner

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 5, 2010


Research teams led by Mayo Clinic have demonstrated for the first time that two types of colorectal pre-cancers can be detected through noninvasive stool DNA testing.

The two studies - presented May 3 and 4 at the 2010 meeting of the American Gastroenterological Association - demonstrate that stool DNA testing may be useful for detection of premalignant dysplasia in patients with inflammatory bowel disease (IBD) and of an important type of colorectal pre-cancer called serrated polyps.

Senior investigator David Ahlquist, MD (www.mayoclinic.org/bio/10006044.html), a Mayo gastroenterologist, said that sensitive stool DNA test methods developed at Mayo Clinic can detect common forerunners of colorectal cancer. "Detection of precursor lesions during screening is essential if cancer prevention is the goal," Dr. Ahlquist says.

Compared to widely used fecal blood tests, stool DNA testing has higher detection rates for curable stage colorectal cancer and for common precancerous polyps (called adenomas).

1. Detection of Colorectal Precancerous Lesions in Inflammatory Bowel Disease

The first study involves identifying both cancer and a precancerous lesion, called dysplasia, in people who suffer from IBD. In a blinded study with 10 cases and 10 controls done in conjunction with Mount Sinai Medical Center and the University of Chicago, researchers found that stool DNA testing was positive in nine out of 10 cases (five of five with cancer, and four of five with dysplasia).

"This study shows that cancer and pre-cancer in IBD can be detected noninvasively," says Dr. Ahlquist. "The 90 percent detection rate by stool DNA testing is remarkable. It's important for people with IBD because they are at much higher risk for colorectal cancer than the general population. Given the limitations of colonoscopies in detecting these lesions, stool DNA testing could play a complementary role to improve the effectiveness of cancer surveillance."

2. Detection of Serrated Colorectal Polyps

The second study involves detecting serrated colorectal polyps. Unlike common adenomas, which usually protrude from the colon lining and are easy to see, serrated polyps are typically flat and the same color as the colon lining.

Dr. Ahlquist says serrated polyps have been ignored or excluded from most screening studies to date because it wasn't clear they were associated with cancer. "Now they are regarded as the forerunner in roughly 30 percent of colon cancers," says Dr. Ahlquist. "Most of these are located on the right side of the colon, where screening has had less impact historically."

For this study, researchers first took tissue and identified two genetic markers that were present in serrated polyps but not in normal colon. The team assayed the markers (mutant BRAF and methylated vimentin genes) in stool samples from 14 cases and 19 control patients who had undergone screening colonoscopies. In blinded fashion, they compared results to fecal blood tests on the same specimens.

"We observed a 71 percent detection rate with stool DNA testing," says Dr. Ahlquist. "This was significantly higher than the 7 percent rate with conventional fecal blood tests."

"Detection of these important types of precancer by stool DNA testing offers promise in our efforts to more effectively and affordably prevent colorectal cancer ," says Dr. Ahlquist. "However, findings from both pilot studies need to be corroborated in larger studies."

Source: Mayo Clinic news release, May 4, 2010




Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Energy NADH™ 12.5mg Guaifenesin FA™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map