ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The best sleeping positions for pain

VIDEO: Anxiety: 11 Things We Want You to Understand

Is There a GERD—Fibro Connection?

Chronic Pain, Loneliness, Depression and Suicide

Beyond pain in fibromyalgia: insights into the symptom of fatigue.

Stair negotiation in women with fibromyalgia: A descriptive correlational study.

Things to Do When You're Mostly Housebound

Is a Good Night's Sleep at the Top of Your Wishlist?

Could a Diet Reduce the Pain in Fibromyalgia? A FODMAPS Study Suggests Yes

Tying the Brain and Body Together in Fibromyalgia?

 
Print Page
Email Article

Quercetin plus dasatinib shows promise for bone maintenance

  [ Not Yet Rated ]   [ Discuss This Article ]
By Life Extension • www.ProHealth.com • September 1, 2017


Quercetin plus dasatinib shows promise for bone maintenance
Reprinted with the kind permission of Life Extension.

August 21 2017. An article appearing August 21, 2017 in Nature Medicine reveals a potential role for senolytic compounds, including quercetin and the drug dasatinib, in the targeting of senescent cells to help maintain bone. "While we know from previous work that the accumulation of senescent cells causes tissue dysfunction, the role of cell senescence in osteoporosis up to this point has been unclear," noted researcher Sundeep Khosla, MD, of the Mayo Clinic's Robert and Arlene Kogod Center on Aging. "The novelty of this work for the bone field lies in the fact that, rather than targeting a bone-specific pathway, as is the case for all current treatments for osteoporosis, we targeted a fundamental aging process that has the potential to improve not only bone mass, but also alleviate other age-related conditions as a group."

The team targeted senescent cells in aged mice with bone loss by several methods, including quercetin plus dasatinib, a genetic model, and a drug that blocks the activity of Janus kinase enzymes to eliminate senescent cell byproducts. "The effects of all three approaches on aging bone were strikingly similar," Dr Khosla reported. "They all enhanced bone mass and strength by reducing bone resorption but maintaining or increasing bone formation, which is fundamentally different from all current osteoporosis drugs."

Dr Khosla’s team determined that the senolytic drugs were only effective when intermittently administered. Dasatinib and quercetin were only given monthly to eliminate senescent cells. "Even though this senolytic drug combination was only present in the mice for a couple of hours, it eliminated senescent cells and had a long-lasting effect," noted co-corresponding author James Kirkland, MD, PhD. "This is another piece of the mounting evidence that senolytic drugs are targeting basic aging processes and could have widespread application in treating multiple chronic diseases."



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Guaifenesin FA™ Fibro Freedom™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes

Natural Remedies

Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map