ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

New Restrictions on Painkillers: Tramadol and Hydrocodone

Small Fiber Neuropathy Fibromyalgia Study Raises Questions

A Fibromyalgia Tale of Two Sisters

Is Venlafaxine Effective for Treating Fibromyalgia?

SURVEY: Cognitive Impairment

The Past, Present and Future of Chronic Pain Treatment

Magnesium: Widespread Deficiency with Deadly Consequences

Can Online Cognitive Behavioral Therapy Help Fibromyalgia?

Disability Claims and Social Media

Increased Sensitivity in Fibromyalgia Not Due to Hypervigilance

 
Print Page
Email Article

Mayo finds unexpected key to lung cancer's first foothold; suggests new approach to treating this and other cancers

  [ 3 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 12, 2012


 Cellular change thought to happen only in late-stage cancers to help tumors spread also occurs in early-stage lung cancer as a way to bypass growth controls, say researchers at Mayo Clinic in Florida.

They believe their discovery, reported July 11 in Science Translational Medicine:

• Provides a new understanding of the extent of transformation that lung cancer - and likely many other tumor types - undergo early in disease development.

• Points to a potential strategy to halt this process, known as epithelial-mesenchymal transition, or EMT. "Our study points to EMT as a key step in lung cancer progression during the earliest stages of cancer development," says lead investigator and cancer biologist Derek Radisky, PhD.

"Normal cells recognize when they are dividing too rapidly, and turn on programs that block inappropriate cell division,” he explains. “Here we found that early-stage lung cancer cells switch on EMT in order to bypass these controls." (EMT is a biological process used in embryonic development to allow body development, which requires the ability of cells and tissues to morph from one type to another, and develop in an orchestrated fashion.)

The discovery could offer a new way to prevent progression to late-stage lung cancer, possibly by inhibiting a particular molecule from functioning, Dr. Radisky says. (Late-stage cancer uses EMT to change tumor cells into a form that can migrate through blood.)

Because EMT is a well-recognized late-stage transition that occurs in all sorts of solid tumors, the researchers say they believe that the same early-stage use of EMT they found in lung cancer is likely occurring in other cancers.

"The gaps in our knowledge of lung cancer have not allowed us to develop more effective targeted therapies," Dr. Radisky says. "This study offers us great new clues for a new approach to treating lung and possibly other cancers as early as possible."

Co-authors include researchers from Mayo Clinic in Rochester, Minn.; University Hospital Giessen and Marburg in Germany; Ontario Cancer Institute in Toronto; and the University of Colorado in Denver.

The study was funded by grants from the National Cancer Institute and the James and Esther King Foundation.

About Mayo Clinic Cancer Center

As a leading institution funded by the National Cancer Institute, Mayo Clinic Cancer Center conducts basic, clinical and population science research, translating discoveries into improved methods for prevention, diagnosis, prognosis and therapy. For information on cancer clinical trials call 507-538-7623.
__
Source: Based on Mayo Clinic press release, Jul 11, 2012
 



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Preserving Cognitive Function with Aging Preserving Cognitive Function with Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing