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Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting - Source: Journal of the Science of Food and Agriculture, Jul 2, 2012

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By Atushi Sano, et al. • • July 20, 2012

[Note:Proanthocyanidins play a role in maintenance and stabilization of collagen and elastin - the connective tissue supporting blood vessels, muscle, organs and joints - and research shows grapeseed extract supports reduced capillary permeability and fragility.]

Background: Leg swelling [edema, fluid trapped in the spaces between cells] is a modern-day affliction of sedentary working women.

The aim of this study was to evaluate the effectiveness of the intake of grape seed extract (GSE) on leg swelling in healthy Japanese women while sitting.

Results: Single intake trials and 14 day intake trials were held in a double-blind, placebo-controlled, crossover clinical study.

A prolonged sedentary position was maintained for 6 hours after GSE or placebo administration.

Leg volume distension, increase in body extracellular fluid, and leg water were significantly suppressed in the GSE groups.

Conclusion: The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting.

Source: Journal of the Science of Food and Agriculture, Jul 2, 2012. PMID:22752876, by Sano A, Tokutake S, Seo A. Research and Development Division, Kikkoman Co., Noda, Japan. [Email:]

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