ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
 
Print Page
Email Article

Constellation of 5 immune markers - may be diagnostic for post mono ME/CFS

  [ 7 votes ]   [ Post a Comment ]
www.ProHealth.com • September 15, 2012

previous article next article

Article:
Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
- Source: Translational Medicine, Sep 13, 2012

By Gordon Broderick, MD, et al.

[Note: A provisional full text PDF of this article is available at http://www.translational-medicine.com/content/pdf/1479-5876-10-191.pdf.  This study by ME/CFS researchers at clinics in Canada and several US states measured a broad range of cytokines, using uniform laboratory protocols, in patients diagnosed according to uniform criteria, all after infection with the same pathogen (Epstein-Barr) and all still ill at 24 months post infection. Cytokines, produced by the immune system, are involved in the inflammatory response.]

Abstract:
Background: As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections, our objective was to describe differences in immune activation in:

• Post-infective CFS (PI-CFS) patients

• And recovered controls.

We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis (IM).

We found an incidence of CFS at 6, 12 and 24 months of 13%, 7% and 4% respectively.

Methods: Using chemiluminescent imaging we measured the concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10, 12 (p70), 13, 15, 17 and 23, IFN-gamma, TNF-alpha and TNF-beta in duplicate plasma samples available in bio-bank from 9 PI-CFS subjects and 12 recovered controls at 24 months post-infection.

Results:

Standard comparative analysis indicated significant differences in IL-8 and 23 across subject groups.

In constructing a linear classification model IL-6, 8 and 23 were selected by two different statistical approaches as discriminating features, with IL-1a, IL-2 and IFN-gamma also selected in one model or the other.

This supported an assignment accuracy of better than 80% at a confidence level of 0.95 into PI-CFS versus recovered controls.

Conclusion: These results suggest that co-expression patterns in as few as 5 cytokines associated with Th17 function may hold promise as a tool for the diagnosis of post-infectious CFS.

Source: Translational Medicine, Sep 13, 2012. PMID: 22973830, by Groderick G, Katz BZ, Fernandes H, Fletcher MA, Klimas NG, Smith FA, O’Gorman MRG, Vernon SD, Taylor R. University of Alberta, Edmonton, Alberta, Canada; Children’s Memorial Hospital, Chicago, Illinois; University of Miami, Florida; Miami Veterans Affairs Medical Center, Miami, Florida; Feinberg School of Medicine, Northwestern, Chicago, Illinois; CFIDS Assoc. of America, Charlotte, North Carolina, USA. [Email: Gordon.broderick@ualberta.ca]



previous article
  Rating 4.7 (7 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Fibro Energy Formula Fibro Energy Formula
13 Top Nutrients for Effective Energy Support
Curcumin, Longvida™ by Nutrivene Curcumin, Longvida™ by Nutrivene
Helps Support Cognition, Memory & Overall Health
Zyflamend® Whole Body by New Chapter Zyflamend® Whole Body by New Chapter
Formulated for Whole Body Healthy Inflammation Response*
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]

FREE: Stop Feeding Yourself PAIN Guide [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing