Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Legs of Fibromyalgia and Myofascial Pain

The Fatigue and Pain Hormone? Leptin Shows Up Again – in Fibromyalgia

Our Mind Wants What Our Body Can't Produce

Relief for Dry, Itchy Skin Caused by Fibromyalgia

Reversing Alzheimer’s: What Could it Mean for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia?

VIDEO: Fibromyalgia Warnings

Recovering from Chronic Fatigue Syndrome and Fibromyalgia - The Lerner Way

4 Simple Ways to Shift into Positivity

3 Reasons Why Fibromyalgia May Affect Women More Than Men

VIDEO: "I Live with Pain Everyday" (Stories of Fibromyalgia)

 
Print Page
Email Article

Combo of drugs affecting pain different ways helped central sensitization

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 7, 2012


Article:
Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
– Source: Pain Practice, Nov 5, 2012 By Chiara Angeletti, MD, et al.

[Note: Duloxetine (Cymbalta) is a serotonin and norepinephrine reuptake inhibitor ('new generation' antidepressant). Pregabalin (Lyrica) is an anticonvulsant. Both are drugs that may be prescribed for fibromyalgia symptoms in the US. Their modes of action are not entirely understood but generally it is thought that duloxetine works on the nerve pathway that inhibits pain, and pregabalin acts on the parts of the nerve that conduct pain signals.]

Abstract: The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases.

Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions.

The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome [rheumatic disease involving eye and ear inflammation].

The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.

Source: Pain Practice (Publication of the World Institute of Pain), Nov 5, 2012. PMID:23126475. Angeletti C, Guetti C, Piroli A, Angeletti PM, Paladini A, Ciccozzi A, Marinangeli F, Varrassi G. Anesthesiology and Pain Medicine, Department of Health Sciences, University of L'Aquila, Italy. [Email: chiara.angeletti@gmail.com]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map