ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
 
Print Page
Email Article

Lyrica and Statin Drug Combo Thought to Cause Rhabdomyolysis: A Case Report

  [ 3 votes ]   [ Post a Comment ]
www.ProHealth.com • November 8, 2012

previous article next article

[Note: to read the full text of the article, click HERE ]

Article:

Pregabalin and simvastatin: first report of a case of rhabdomyolysis
– Source: Pharmacy and Therapeutics, October 2012

by Michele B. Kaufman and Mary Choy

Abstract:

Purpose: We sought to determine whether a case of rhabdomyolysis was a probable adverse reaction associated with pregabalin (Lyrica) and simvastatin (Zocor). [Note: Rhabdomyolysis is the breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream. Myoglobin is harmful to the kidney and often causes kidney damage.] Pregabalin is not recognized as a cause of rhabdomyolysis, but statins are known to cause it.

 

Patient Summary: A 70-year-old man with a history of fibromyalgia, type-2 diabetes, hypercholesterolemia, and chronic back pain presented to the emergency department with altered mental status, limb weakness, twitching, and slurred speech.

 

He was taking multiple pain and neuropathic medications and had recently started taking lisinopril (e.g., Zestril) and simvastatin. His pregabalin dose was also increased from 50 mg to 100 mg three times daily. On admission, serum creatinine (SCr) and creatine phosphokinase (CPK) levels were 1.5 mg/dL (normal, 0.7-1.5 mg/dL) and 1,391 units/L (normal, 30-170 units/L), respectively. Metformin (Glucophage) was discontinued, and insulin was started.

 

He was alert and oriented. The review of symptoms was normal except for leg weakness. He had no seizure activity. Simvastatin was discontinued, and the patient was aggressively hydrated. The following day, the SCr level was 1.6 mg/dL and the CPK level was 14,191 units/L. Pregabalin was then discontinued.

 

The rhabdomyolysis resulted from simvastatin and perhaps also pregabalin. The Naranjo Causality Algorithm indicates a probable relationship between rhabdomyolysis and combined therapy. Three days later, the patient had significantly improved, and CPK began to decline. His discharge plan included all prior medications except simvastatin and pregabalin.

 

Conclusion: It is not well known that pregabalin can cause rhabdomyolysis, and there is only one published report on pregabalin-induced hepatotoxicity. [Note: The full-text article also states, “In the package labeling for pregabalin, three cases of rhabdomyolysis are noted in premarketing clinical trials; however, no further details are provided.”] When different therapies are combined, the risk of rhabdomyolysis may be increased.

 

The cause of rhabdomyolysis in our patient might be related to decreased renal elimination of both pregabalin and simvastatin (e.g., renal tubular reabsorption). It is important to be aware of this potentially serious and possibly life-threatening reaction especially when medication doses are increased or combined with other agents with similar safety issues.

Source: Pharmacy and Therapeutics. 2012 Oct; 37(10):579-95, by Michele B. Kaufman, PharmD and Mary Choy, PharmD.



previous article
  Rating 5 (3 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Curcumin, Longvida™ by Nutrivene Curcumin, Longvida™ by Nutrivene
Helps Support Cognition, Memory & Overall Health
Zyflamend® Whole Body by New Chapter Zyflamend® Whole Body by New Chapter
Formulated for Whole Body Healthy Inflammation Response*
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Fibro Energy Formula Fibro Energy Formula
13 Top Nutrients for Effective Energy Support

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing