ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Where Fibromyalgia and Chronic Fatigue Syndrome Part Ways (and Where They Don't)

Autoimmune Research Opening Up New Options for Chronic Pain Sufferers

Celiac Symptoms in Fibromyalgia Patients

Does Fibromyalgia Diet = Deprivation?

Why Pain, Fatigue, FibroFog, and Sleep Are Results Symptoms

Accepting and Surviving Chronic Illness

Abnormal Cerebral Blood Flow Affects Cognitive Function in Fibromyalgia

FDA Approves New Type of Sleep Medication

How to Become a Fibromyalgia Truth Sleuth

VIDEO: Healthy Eating and Fibromyalgia

 
Print Page
Email Article

Could Alzheimer’s Be as Simple as Herpes Simplex?

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 20, 2012


Article:
Intracerebral propagation of Alzheimer’s disease: Strengthening evidence of a herpes simplex virus etiology
– Source: Alzheimer’s & Dementia, Nov 16, 2012

By Melvyn J Ball, et al.

[Note: This fee-based article by researchers at Oregon Health & Science University in Portland reviews data supporting a list of reasons for pursuing their theory of how damage may spread in the Alzheimer’s brain via the HSV-1 virus known to produce most ‘cold sores’.] 

Abstract:
Background: A faulty human protein, abnormally phosphorylated tau, was recently publicized to spread “like a virus” from neuron to neuron in Alzheimer’s patients’ brains.

For several decades, we have been amassing arguments showing that herpes simplex virus type 1 (HSV-1), not p-tau, propagates this interneuronal, transsynaptic pathologic cascade.

Methods: We reiterate convincing data from our own (and other) laboratories, reviewing:

• The first anatomic foothold neurofibrillary tangles gain in brainstem and/or entorhinal cortex;

• The chronic immunosurveillance cellularity of the trigeminal ganglia wherein HSV-1 awakens from latency to reactivate;

• The inabilities of p-tau protein's physical properties to promote it to jump synapses;

• The amino acid homology between human p-tau and VP22, a key target for phosphorylation by HSV serine/threonine–protein kinase UL13;

• And the exosomic secretion of HSV-1–infected cells’ L-particles, attesting to the cell-to-cell passage of microRNAs of herpesviruses.

Results:
The now-maturing construct that reactivated HSV-1 best accounts for the intracerebral propagation of AD changes in the human brain should at last seem highly attractive.

This hypothesis might even explain statins' apparent mechanism in some studies for lowering AD incidence.

Conclusion: Provided that funding agencies will quickly ignite a new realm of investigation, the rejuvenated enthusiasm for testing this optimistic construct holds incalculable potential for:

• Rapid, efficacious clinical application,

• Through already available and relatively safe antiviral therapeutics.

Source: Alzheimer’s & Dementia, Nov 16, 2012. PMID:23159044, by Ball MJ, Lukiw WJ, Kammerman EM, Hill JM. Departments of Pathology and Neurology, Oregon Health & Science University, Portland, Oregon, USA. [Email: ballm@ohsu.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
The Curcumin Revolution: The Curcumin Revolution: "Golden" Ticket to Better Health
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Preserving Cognitive Function with Aging Preserving Cognitive Function with Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing