ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Namenda (memantine): A Potential NEW Treatment for Fibromyalgia

Daytime Napping Linked to Increased Fibromyalgia Symptom Severity

Minimizing Fibromyalgia Symptoms: Valuable Lessons from Childhood

An Update on Drugs Used for Treating Fibromyalgia

Respiratory Sinus Arrhythmia and Its Association with Pain in Women with Fibromyalgia

SURVEY: What Triggered Your Illness?

Why I Became a Fibromyalgia Advocate

5 Tips for When Motivation Runs Out

There's This Friend I Have...

Neuro-inflammation II: The Kynurenine Pathway in Fibromyalgia and ME/CFS

 
Print Page
Email Article

Could Alzheimer’s Be as Simple as Herpes Simplex?

  [ 7 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 20, 2012


Article:
Intracerebral propagation of Alzheimer’s disease: Strengthening evidence of a herpes simplex virus etiology
– Source: Alzheimer’s & Dementia, Nov 16, 2012

By Melvyn J Ball, et al.

[Note: This fee-based article by researchers at Oregon Health & Science University in Portland reviews data supporting a list of reasons for pursuing their theory of how damage may spread in the Alzheimer’s brain via the HSV-1 virus known to produce most ‘cold sores’.] 

Abstract:
Background: A faulty human protein, abnormally phosphorylated tau, was recently publicized to spread “like a virus” from neuron to neuron in Alzheimer’s patients’ brains.

For several decades, we have been amassing arguments showing that herpes simplex virus type 1 (HSV-1), not p-tau, propagates this interneuronal, transsynaptic pathologic cascade.

Methods: We reiterate convincing data from our own (and other) laboratories, reviewing:

• The first anatomic foothold neurofibrillary tangles gain in brainstem and/or entorhinal cortex;

• The chronic immunosurveillance cellularity of the trigeminal ganglia wherein HSV-1 awakens from latency to reactivate;

• The inabilities of p-tau protein's physical properties to promote it to jump synapses;

• The amino acid homology between human p-tau and VP22, a key target for phosphorylation by HSV serine/threonine–protein kinase UL13;

• And the exosomic secretion of HSV-1–infected cells’ L-particles, attesting to the cell-to-cell passage of microRNAs of herpesviruses.

Results:
The now-maturing construct that reactivated HSV-1 best accounts for the intracerebral propagation of AD changes in the human brain should at last seem highly attractive.

This hypothesis might even explain statins' apparent mechanism in some studies for lowering AD incidence.

Conclusion: Provided that funding agencies will quickly ignite a new realm of investigation, the rejuvenated enthusiasm for testing this optimistic construct holds incalculable potential for:

• Rapid, efficacious clinical application,

• Through already available and relatively safe antiviral therapeutics.

Source: Alzheimer’s & Dementia, Nov 16, 2012. PMID:23159044, by Ball MJ, Lukiw WJ, Kammerman EM, Hill JM. Departments of Pathology and Neurology, Oregon Health & Science University, Portland, Oregon, USA. [Email: ballm@ohsu.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing