ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

New Restrictions on Painkillers: Tramadol and Hydrocodone

A Fibromyalgia Tale of Two Sisters

Energy-Boosting Fibromyalgia Superfoods

SURVEY RESULTS: Pain Treatments

Small Fiber Neuropathy Fibromyalgia Study Raises Questions

Is Venlafaxine Effective for Treating Fibromyalgia?

Can Online Cognitive Behavioral Therapy Help Fibromyalgia?

The Past, Present and Future of Chronic Pain Treatment

Fibromyalgia Associated with Decreased Connectivity Between Pain-Related and Sensorimotor Areas of B...

Increased Sensitivity in Fibromyalgia Not Due to Hypervigilance

 
Print Page
Email Article

Melatonin Plays a Role in Reducing Pain Sensitivity

  [ 39 votes ]   [ 1 Comment ]
www.ProHealth.com • December 7, 2012


Melatonin Plays a Role in Reducing Pain SensitivityArticle:

Melatonin in antinociception: its therapeutic applications. 
– Source: Current Neuropharmacology, June 2012.

By V. Srinivasan, et al.

Abstract:

The intensity of pain sensation exhibits marked day and night variations. Since the intensity of pain perception is low during dark hours of the night when melatonin levels are high, this hormone has been implicated as one of the prime antinociceptive [reducing sensitivity to painful stimuli] substances.

A number of studies have examined the antinociceptive role of melatonin in acute, inflammatory and neuropathic pain animal models.

  • It has been demonstrated that melatonin exerts antinociceptive actions by acting at both spinal cord and supraspinal levels.

  • The mechanism of antinociceptive actions of melatonin involves opioid, benzodiazepine, a(1)- and a(2)-adrenergic, serotonergic and cholinergic receptors.

  • Most importantly however, the involvement of MT(1)/MT(2) melatonergic receptors in the spinal cord has been well documented as an antinociceptive mechanism in a number of animal models of pain perception.

  • Exogenous melatonin [melatonin produced outside the body; i.e., in supplement form] has been used effectively in the management of pain in medical conditions such as fibromyalgia, irritable bowel syndrome and migraine and cluster headache.

  • Melatonin has been tried during surgical operating conditions and has been shown to enhance both preoperative and post-operative analgesia.

The present review discusses the available evidence indicating that melatonin, acting through MT(1)/MT(2) melatonin receptors, plays an important role in the pathophysiological mechanism of pain.

Source: Current Neuropharmacology, June 2012. By V. Srinivasan, E.C. Lauterbach, K.Y. Ho, D. Acuna-Castroviejo, R. Zakaria, A. Brzezinski. Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, 40 Kovai Thirunagar, Coimbatore-641014, Tamilnadu, India.

 




Please Discuss This Article:   Post a Comment 

Melatonin
Posted by: IanH
Dec 8, 2012
The dose of melatonin required for antinociception (painreducingg) is 10mg to 30mg. Some studies have used more than this. Any dosage lower than this has not been shown to be effective. It takes a while to get used to the slight somnolence induced by this dose.

To review this look up the Journal Of Pineal Research. Some of the papers are free to view.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
5-HTP Extra Strength 200mg 5-HTP Extra Strength 200mg
Increase Serotonin Levels Naturally
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion

Natural Remedies

The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing