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How Chronic Fatigue Syndrome Patients Respond to Flu Vaccine

  [ 14 votes ]   [ 1 Comment ] • January 28, 2013

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[Note: You may read the full text of this article free HERE.]


Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome
– Source: BMC Immunology, December 17, 2012

By Hetty Prinsen, et al.


Chronic fatigue syndrome (CFS) is a clinical condition characterized by severe and disabling fatigue that is medically unexplained and lasts longer than 6 months. Although it is possible to effectively treat CFS, the nature of the underlying physiology remains unclear. Various studies have sought evidence for an underlying disturbance in immunity. The aim of this study was to compare the humoral [relating to the part of the immune response that involves antibodies secreted by B cells and circulating in bodily fluids] and cellular immune responses upon influenza vaccination in CFS patients and healthy controls.

Identical antibody titers were observed in CFS patients and healthy controls. Patients and controls demonstrated similar seroprotection rates against all three virus-strains of the influenza vaccine, both pre- and post-vaccination. Functional T cell reactivity was observed in both CFS patients and healthy controls. CFS patients showed a non-significant, numerically lower cellular proliferation at baseline compared to controls. Vaccination induced a significant increase in cellular proliferation in CFS patients, but not in healthy controls. Cytokine production and the number of regulatory T cells were comparable in patients and controls.

The humoral and cellular immune responses upon influenza vaccination were comparable in CFS patients and healthy controls. Putative aberrations in immune responses in CFS patients were not evident for immunity towards influenza. Standard seasonal influenza vaccination is thus justified and, when indicated, should be recommended for patients suffering from CFS.

BMC Immunology, December 17, 2012. By Hetty Prinsen, I Jolanda M. deVries, Ruurd Torensma, Jeanette M. Pots, Sasja F. Mulder, Carla M.L. Van Herpen, Lammy D. Elving, Gijs Bleijenberg, Foekje F. Stelma and Hanneke W. M. van Laarhoven. Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525, GA, Nijmegen, the Netherlands; Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Expert Centre for Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Department of Medical Oncology, Academic Medical Center University of Amsterdam, Amsterdam, the Netherlands.

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DISCUSS THIS ARTICLE   (1 existing comment) Post a Comment 

yes, but...
Posted by: Sandy10m
Mar 20, 2013
That's great news that the flu vaccine might have the same effect on the antibodies, but what about the number of patients that actually got the flu from the flu shot? I'm one of those people who almost always gets the flu after the shot. And it takes a really long time for my arm to recover. CFS patients have notoriously funky immune systems, overreacting to normal stuff like foods and scents, and not reacting at all to colds and flu (getting sick all the time). We need information about THAT and what to do about it. I'm trying the low-dose Naltrexone to mediate my immune system, and it's working very well so far.
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