ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The New Me

Eli Lilly Settles Cymbalta Withdrawal Lawsuits

Top Fibromyalgia Drug Tanks: Four Other Drugs On Way

When Retreat Means Advance: A Recovered Chronic Fatigue Syndrome/Fibromyalgia Patient Looks Back

A Genetic Panel for Fibromyalgia? The New Proove Genetic Test

Fibromyalgia Life Lessons - What You Need to Know.

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

Genes May Be Causing Neuroinflammation and Pain in Fibromyalgia

Pacing through the Perils of Fibromyalgia

The Psychosocial Disease – Has Fibromyalgia Been Captured by a Behavioral Paradigm?

Print Page
Email Article

Lower Levels of ATP and PCr Found in Muscles of Fibromyalgia Patients

  [ 20 votes ]   [ Discuss This Article ] • February 7, 2013

[Note:  ATP stands for adenosine triphosphate, which is described as the energy currency of life.  Mitochondria are the energy producers in each cell and they supply this energy in the form of ATP.  PCr stands for phosphocreatinine, an organic compound found in muscle tissue that stores and provides energy for muscular contraction.]


Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients - A (31) P-MRS study.

– Source: European Journal of Pain, January 30, 2013

by G. Gerdle, et al.


BACKGROUND AND METHODS: Fibromyalgia (FMS) has a prevalence of approximately 2% in the population. Central alterations have been described in FMS, but there is not consensus with respect to the role of peripheral factors for the maintenance of FMS.

( 31) P Magnetic Resonance Spectroscopy ((31) P-MRS) has been used to investigate the metabolism of phosphagens in muscles of FMS patients, but the results in the literature are not in consensus. The aim was to investigate the quantitative content of phosphagens and pH in resting quadriceps muscle of patients with FMS (n?=?19) and in healthy controls (Controls; n?=?14) using (31) P-MRS. It was also investigated whether the concentrations of these substances correlated with measures of pain and/or physical capacity.


  • Significantly lower concentrations of adenosine triphosphate (ATP) and phosphocreatinine (PCr; 28-29% lower) were found in FMS.

  • No significant group differences existed with respect to inorganic phosphate (Pi), Pi/PCr and pH.

  • The quadriceps muscle fat content was significantly higher in FMS than in Controls [FMS: 9.0?±?0.5% vs. Controls: 6.6?±?0.6%; (mean?±?standard error); P?=?0.005].

  • FMS had significantly lower hand and leg capacity according to specific physical test, but there were no group differences in body mass index, subjective activity level and in aerobic fitness.

  • In FMS, the specific physical capacity in the leg and the hand correlated positively with the concentrations of ATP and PCr; no significant correlations were found with pain intensities.

CONCLUSIONS: Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.

Source: European Journal of Pain, January 30, 2013. B. Gerdle, M.F. Forsgren, A. Bengtsson, O.D. Leinhard, B. Soren, A. Karlsson, V. Brandejsky, E. Lund, P. Lundberg.  Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Sweden; Pain and Rehabilitation Centre, UHL, Linköping, Sweden.

Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Hydroxocobalamin Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map