ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Cognitive Dysfunction in Fibromyalgia: Slow Access to the Mental Lexicon

Fibromyalgia Flares: A Qualitative Analysis

Basil Essential Oil Has Analgesic Effect on Mice Model of Fibromyalgia

Effects of a Gluten-Free Diet on IBS and Fibromyalgia

10 Timer Tips for Healthy Fibromyalgia Support

NIH Panel Cites Need for Individualized, Patient-Centered Approach to Treat Chronic Pain

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

Cognitive Differences Between Men and Women with Fibromyalgia

The Importance of Acceptance

How Does a Functional Restoration Program Affect Fibromyalgia?

 
Print Page
Email Article

Ubiquinol (CoQ10) Improves Fatigue and Cholesterol Levels in Juvenile Fibromyalgia

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • February 20, 2013


Article:

Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.
– Source: Redox Report, January 2013

By T. Miyamae, et al.

Abstract:

Fibromyalgia (FM) is characterized by generalized pain and chronic fatigue of unknown etiology. To evaluate the role of oxidative stress in this disorder, we measured plasma levels of ubiquinone-10, ubiquinol-10, free cholesterol (FC), cholesterol esters (CE), and free fatty acids (FFA) in patients with juvenile FM (n = 10) and in healthy control subjects (n = 67).

  • Levels of FC and CE were significantly increased in juvenile FM as compared with controls, suggesting the presence of hypercholesterolemia in this disease.

  • However, plasma level of ubiquinol-10 was significantly decreased and the ratio of ubiquinone-10 to total coenzyme Q10 (%CoQ10) was significantly increased in juvenile FM relative to healthy controls, suggesting that FM is associated with coenzyme Q10 deficiency and increased oxidative stress.

  • Moreover, plasma level of FFA was significantly higher and the content of polyunsaturated fatty acids (PUFA) in total FFA was significantly lower in FM than in controls, suggesting increased tissue oxidative damage in juvenile FM.

  • Interestingly, the content of monoenoic acids, such as oleic and palmitoleic acids, was significantly increased in FM relative to controls, probably to compensate for the loss of PUFA.

Next, we examined the effect of ubiquinol-10 supplementation (100 mg/day for 12 weeks) in FM patients.

  • This resulted in an increase in coenzyme Q10 levels and a decrease in %CoQ10.

  • No changes were observed in FFA levels or their composition.

  • However, plasma levels of FC and CE significantly decreased and the ratio of FC to CE also significantly decreased, suggesting that ubiquinol-10 supplementation improved cholesterol metabolism.

  • Ubiquinol-10 supplementation also improved chronic fatigue scores as measured by the Chalder Fatigue Scale.


Source: Redox Report, January 2013. By T. Miyamae, M. Seki, T. Naga, S. Uchino, H. Asazuma, T. Yoshida, Y. Iizuka, M. Kikuchi, T. Imagawa, Y. Natsumeda, S. Yokota, Y. Yamamoto. Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing