ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Eli Lilly Settles Cymbalta Withdrawal Lawsuits

Top Fibromyalgia Drug Tanks: Four Other Drugs On Way

When Retreat Means Advance: A Recovered Chronic Fatigue Syndrome/Fibromyalgia Patient Looks Back

A Genetic Panel for Fibromyalgia? The New Proove Genetic Test

Fibromyalgia Life Lessons - What You Need to Know.

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

The Psychosocial Disease – Has Fibromyalgia Been Captured by a Behavioral Paradigm?

Genes May Be Causing Neuroinflammation and Pain in Fibromyalgia

3 Fibromyalgia Struggles I’m Glad I Had

VIDEO: How does your brain respond to pain?

Print Page
Email Article

Inflammation in the gut may lead to the proliferation of unhealthy gut flora

  [ 3 votes ]   [ 1 Comment ] • February 23, 2013

Editor's Comment: This piece of research directly supports Martin Pall's hypothesis that the production of excess nitric oxide is the basic mechanism behind ME/CFS. According to Pall, the symptoms of ME/CFS and other multi-system illnesses can be explained by a vicious cycle of inflammation created by nitric oxide and its breakdown products. This study also provides an explanation for the gut flora abnormalities and subsequent gastrointestinal problems commonly experienced by people with ME/CFS, IBS, autism, and fibromyalgia.

Host-derived nitrate boosts growth of E. coli in the inflamed gut.

~Source: Science. February 8, 2013.

By SE Winter et al.


Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice. Mice deficient in inducible nitric oxide synthase did not support the growth of E. coli by nitrate respiration, suggesting that the nitrate generated during inflammation was host-derived. Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration.

Source: Science. 2013 Feb 8;339(6120):708-11. doi: 10.1126/science.1232467. Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM,Stewart VJ, Bäumler AJ. Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA, USA.

Additional information about this study can be found at Science Daily.

Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Fibro Freedom™ Guaifenesin FA™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

Pall, possibly
Posted by: IanH
Feb 23, 2013
The key statement from the authors is "We show that nitrate generated as a by-product of the inflammatory response"

The key is "inflammatory response" which is now well established in ME/CFS.
Reply Reply
Natural Pain Relief Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates

Natural Remedies

How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map