ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tired of Your Every Night 2 AM Wake-Up Call?

Muscle Trigger Points and Pressure Pain Sensitivity Maps of the Feet in Women with Fibromyalgia Synd...

The Challenges of Being a Sick Parent

When You Are Frustrated with Healthcare Professionals

How to be Broke and Medicated with Fibromyalgia or ME/CFS

Snooze News – The conundrum of sleep deprivation

How Not to Treat Brain Fog

Massage for Pain: An Evidence Map

Fibromyalgia and Cancer Related Fatigue

Do you fall asleep easily during the day? Diagnosing and Treating Sleep Apnea

 
Print Page
Email Article

Inflammation in the gut may lead to the proliferation of unhealthy gut flora

  [ 3 votes ]   [ 1 Comment ]
www.ProHealth.com • February 23, 2013


Editor's Comment: This piece of research directly supports Martin Pall's hypothesis that the production of excess nitric oxide is the basic mechanism behind ME/CFS. According to Pall, the symptoms of ME/CFS and other multi-system illnesses can be explained by a vicious cycle of inflammation created by nitric oxide and its breakdown products. This study also provides an explanation for the gut flora abnormalities and subsequent gastrointestinal problems commonly experienced by people with ME/CFS, IBS, autism, and fibromyalgia.

Host-derived nitrate boosts growth of E. coli in the inflamed gut.

~Source: Science. February 8, 2013.

By SE Winter et al.

Abstract

Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice. Mice deficient in inducible nitric oxide synthase did not support the growth of E. coli by nitrate respiration, suggesting that the nitrate generated during inflammation was host-derived. Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration.

Source: Science. 2013 Feb 8;339(6120):708-11. doi: 10.1126/science.1232467. Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM,Stewart VJ, Bäumler AJ. Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA, USA.

Additional information about this study can be found at Science Daily.




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Hydroxocobalamin Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Pall, possibly
Posted by: IanH
Feb 23, 2013
The key statement from the authors is "We show that nitrate generated as a by-product of the inflammatory response"

The key is "inflammatory response" which is now well established in ME/CFS.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map