Activate Now
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Aromatherapy Diffusers For Fibromyalgia Support

Chronic Fatigue Syndrome, Fibromyalgia and Mitchondrial Disorders: A Comparison Plus the MitoQ Trial...

Dr. Teitelbaum's 3 Steps to Fibromyalgia Pain Relief - Part 1: Understanding Fibromyalgia Pain

An Interview with Ken McKim: Educating the public about chronic illness

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Are All the "Feel-Good" Pathways Blocked in Fibromyalgia and Chronic Fatigue Syndrome?

5 Things I've Learned About Chronic Illness Through Mindfulness

SURVEY RESULTS: Has Your Illness Affected What You Eat?

Staying healthy from fibromyalgia is ongoing hard work

Cellular Havoc: Zeroing In On The Sleep Problems in Fibromyalgia?

Print Page
Email Article

Long-Term Effects of Savella for Fibromyalgia Evaluated

  [ 6 votes ]   [ Discuss This Article ] • March 4, 2013


A 3-Year, Open-Label, Flexible-Dosing Study of Milnacipran for the Treatment of Fibromyalgia.
– Source: The Clinical Journal of Pain, February 26, 2013

By L.M. Arnold, R.H. Palmer and Y. Ma


OBJECTIVES: To evaluate the effects of long-term milnacipran [brand name Savella] treatment in fibromyalgia patients.

Patients completing a previous milnacipran study were eligible to participate in this long-term (up to 3.25 y), open-label study. After washout, dose escalation, and 8 weeks of stable-dose treatment (100 mg/d), patients received flexible doses of milnacipran (50 to 200 mg/d) for the remainder of the study.

Safety evaluations included adverse events and vital signs. Clinical measures included weekly recall pain [visual analog scale (VAS)], Patient Global Disease Status (PGDS), and the Short Form-36 Health Survey [SF-36, including the Physical Component Summary (PCS) and Mental Component Summary scores]. Cohort analyses were conducted to assess the effects of milnacipran over varying periods of time.

RESULTS: Of 1227 patients entering the study, 585 (47.7%) were classified as completers, including 379 (30.9%) patients who were currently enrolled when the study was administratively terminated. Mean duration of treatment was 19 months, with 206 patients reaching the final visit and receiving 36 to 38 months of study treatment.

  • The percentage of patients with ?1 treatment-emergent adverse event was 88.3%, with nausea (25.9%) and headache (13.4%) being the most common events.

  • Discontinuations due to adverse events occurred in 20.9% of patients.

  • Potentially clinically significant increases in blood pressure or heart rate occurred in ?1.1% of patients.

  • Mean improvement from baseline in weekly recall VAS pain was 17.6; improvements in global status (PGDS) and physical functioning (SF-36 PCS) were also observed.

  • In all patient cohorts, these improvements were observed by month 3 and remained relatively constant over time.

  • At final study visit in the 3-year cohort, 70.3% of patients rated their overall fibromyalgia as "much improved" or "very much improved."

DISCUSSION: No new safety concerns were identified in this long-term study. Sustained symptom improvements were found in fibromyalgia patients who received up to 3.25 years of milnacipran treatment.

Source: The Clinical Journal of Pain, February 26, 2013. By L.M. Arnols, R.H. Palmer and Y. Ma. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH; Forest Research Institute Inc., Jersey City, NJ.

Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ Optimized Curcumin Longvida® Fibro Freedom™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing