ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Blood Test for Fibromyalgia: FM/a® Test is Real

Wired to Eat – The Best Diet Plan for ME/CFS and Fibromyalgia?

The Big Hurt: Second Major Fibromyalgia Drug in a Year Fails

New Device Treats Widespread Fibromyalgia and Lyme-Related Pain

It’s a Battlefield: Fibromyalgia and Bruising

What are Your Spoons Worth?

An open letter to Eli Lilly and all patients affected by Cymbalta's withdrawal symptoms

3 Things that Give Me Back More Energy Than They Take

12 bloggers share their best tips for reducing fibromyalgia symptoms

VIDEO: Fibromyalgia Pain Relief Stretching Program: Gentle but Effective

 
Print Page
Email Article

Altered Functional B Cell Subset Populations in Patients With Chronic Fatigue Syndrome Compared to Healthy Controls

  [ 4 votes ]   [ 1 Comment ]
By A. S. Bradley et al. • www.ProHealth.com • March 21, 2013


Editor's Note: Naive B cells are immune system cells that have not been exposed to an antigen, that is, they have not "learned" to identify an invader. Plasmablasts perform a similar function. Transitional B cells are cells that have not yet been transformed into different classes of immune cells. A large proportion of immature B cells leads to a decrease in a person's ability to combat previously encountered pathogens (humoral immunity). A shift toward increased numbers of immature B cells is found in autoimmune disease, such as lupus.

~Source: Clinical & Experimental Immunology, April 2013

By A. S. Bradley et al.

Summary

Chronic fatigue syndrome (CFS) is a heterogeneous disorder of unknown aetiology characterized by disabling fatigue, headaches, sleep disturbance and several other symptoms. The onset of CFS may follow a viral infection or period of stress. Patients with CFS do not have hypogammaglobulinaemia, predisposition to recurrent bacterial infections or symptoms of autoimmunity. To date, defects in B cell numbers or function have not been shown in the literature. However, treatment with anti-B cell therapy using Rituximab has recently shown benefit to CFS patients. We therefore postulated that patients with CFS had a subtle humoral immune dysfunction, and performed extended B cell immunophenotyping. We undertook a detailed characterization of the proportions of the different B cell subsets in 33 patients with CFS fulfilling the Canadian and Fukada criteria for CFS and compared these with 24 age- and gender-matched healthy controls (HC). CFS patients had greater numbers of naive B cells as a percentage of lymphocytes: 6.3 versus 3.9% in HC (P?=?0.034), greater numbers of naive B cells as a percentage of B cells: 65 versus 47% in controls (P?=?0.003), greater numbers of transitional B cells: 1.8 versus 0.8% in controls (P?=?0.025) and reduced numbers of plasmablasts: 0.5 versus 0.9% in controls (P?=?0.013). While the cause of these changes is unclear, we speculate whether they may suggest a subtle tendency to autoimmunity.

Source: Clinical & Experimental Immunology, Volume 172, Issue 1, pages 73–80, April 2013 A. S. Bradley, B. Ford, A. S. Bansal.





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Hydroxocobalamin Extreme™ FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Not only autoimmunity
Posted by: IanH
Mar 21, 2013
This is the same state that exists in AIDS so besides autoimmunity it suggests a viral induced immuno-suppression.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map