Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Legs of Fibromyalgia and Myofascial Pain

The Fatigue and Pain Hormone? Leptin Shows Up Again – in Fibromyalgia

Our Mind Wants What Our Body Can't Produce

Relief for Dry, Itchy Skin Caused by Fibromyalgia

Reversing Alzheimer’s: What Could it Mean for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia?

VIDEO: Fibromyalgia Warnings

4 Simple Ways to Shift into Positivity

Recovering from Chronic Fatigue Syndrome and Fibromyalgia - The Lerner Way

VIDEO: "I Live with Pain Everyday" (Stories of Fibromyalgia)

3 Reasons Why Fibromyalgia May Affect Women More Than Men

 
Print Page
Email Article

Carnosine Improves Cognitive Function in Gulf War Illness, Implications for CFS/ME

  [ 7 votes ]   [ 1 Comment ]
www.ProHealth.com • April 28, 2013


Editor's Comment: Carnosine, a dipeptide composed of the amino acids histidine and beta-alanine, is found abundantly in muscle and brain tissue. A number of studies have found that carnosine is a potent free-radical scavenger, and can mitigate against the damaging effects of aldehydes created by the peroxidation of cell membrane fatty acids (oxidative stress). Because roughly 50% of the brain is fat, carnosine may have significant benefits for people with neurological impairments caused by oxidative stress. Dr. Paul Cheney, Dr. Martin Pall, and others, have cited evidence of increased peroxidation of cell membrane fatty acids among patients with CFS/ME. It is noteworthy that the veterans who participated in this study also met the criteria for CFS/ME.

Note: The full article can be accessed from the abstract.

Carnosine Treatment for Gulf War Illness: A Randomized Controlled Trial

By James N. Baraniuk et al.

Abstract

About 25% of 1990-1991 Persian Gulf War veterans experience disabling fatigue, widespread pain, and cognitive dysfunction termed Gulf War illness (GWI) or Chronic Multisymptom Illness (CMI). A leading theory proposes that wartime exposures initiated prolonged production of reactive oxygen species (ROS) and central nervous system injury. The endogenous antioxidant L-carnosine (B-alanyl-L-histidine) is a potential treatment since it is a free radical scavenger in nervous tissue. To determine if nutritional supplementation with L-carnosine would significantly improve pain, cognition and fatigue in GWI, a randomized double blind placebo controlled 12 week dose escalation study involving 25 GWI subjects was employed. 

L-carnosine was given as 500, 1000, and 1500 mg increasing at 4 week intervals. Outcomes included subjective fatigue, pain and psychosocial questionnaires, and instantaneous fatigue and activity levels recorded by ActiWatch Score devices. Cognitive function was evaluated by WAIS-R digit symbol substitution test. 

Carnosine had 2 potentially beneficial effects: WAIS-R scores increased significantly, and there was a decrease in diarrhea associated with irritable bowel syndrome. No other significant incremental changes were found. Therefore, 12 weeks of carnosine (1500 mg) may have beneficial cognitive effects in GWI. Fatigue, pain, hyperalgesia, activity and other outcomes were resistant to treatment.

Source: Journal of Health Science; Vol. 5, No. 3; 2013. James N. Baraniuk, Suliman El-Amin, Rebecca Corey, Rakib U. Rayhan & Christian R. Timbol.





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Hydroxocobalamin Extreme™ Fibro Freedom™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

add the following
Posted by: IanH
Apr 28, 2013
B12 and CoQ10 to the carnosine and you will getter better results
For longer term improvements add vitamin D3 with B12 and CoQ10

I have tested several people after treatment with B12+CoQ10+Carnosine for a range of cognitive functions using the 3MS, after treatment with B12+CoQ10+Carnosine which is a wider range test than the Wais.

Results are mixed but significant. Not enough subjects to do a report though.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
"It's Not Easy Being Green" - But It Is Healthy

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map