ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

New Restrictions on Painkillers: Tramadol and Hydrocodone

A Fibromyalgia Tale of Two Sisters

Energy-Boosting Fibromyalgia Superfoods

Small Fiber Neuropathy Fibromyalgia Study Raises Questions

Is Venlafaxine Effective for Treating Fibromyalgia?

Can Online Cognitive Behavioral Therapy Help Fibromyalgia?

The Past, Present and Future of Chronic Pain Treatment

Fibromyalgia Associated with Decreased Connectivity Between Pain-Related and Sensorimotor Areas of B...

Increased Sensitivity in Fibromyalgia Not Due to Hypervigilance

Reduced Intraepidermal Nerve Fiber Density in Skin of Fibromyalgia Patients

 
Print Page
Email Article

CoQ10 Reduces Inflammation and Enhances Antioxidant Activity in Patients With Coronary Artery Disease

  [ 18 votes ]   [ 1 Comment ]
By Erica Verrillo • www.ProHealth.com • November 12, 2013


Research Summary: Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.

At the May 2013 Heart Failure Congress a randomized double blind trial was presented showing that CoQ10 caused a 50% decrease in mortality from all cardiac events. As this was the first treatment in over a decade to improve heart failure mortality, the news made headlines in the scientific community. Other CoQ10 studies were bound to follow. 

The most recent study to focus on the benefits of CoQ10 for heart health comes from Taiwan, where a group of researchers in Taichung studied the effects of CoQ10 supplementation on patients receiving statins (cholesterol-reducing drugs). Statins have been shown to reduce the biosynthesis of CoQ10, a powerful antioxidant found in nearly all cells of the human body. (CoQ10 works to produce energy in mitochondria, and is the only antioxidant that humans can synthesize.) The researchers investigated the effects that supplementation with CoQ10 might have on patients during statin therapy, particularly its effect on inflammatory markers which are directly correlated with coronary artery disease. 

A cohort of 54 patients with 50% stenosis of at least one coronary artery was divided into two groups. Twenty-seven patients were randomly chosen to receive 300mg of CoQ10 daily for twelve weeks, while twenty-four received placebo. Concentrations of coenzyme Q10 and vitamin E were measured in the two groups, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase. Inflammatory markers - C reactive protein (CRP), tumor necrosis factor-alpha and interleukin-6 - were measured in the 42 subjects who completed the study.

At the end of twelve weeks, the researchers found that plasma levels of CoQ10 as well as antioxidant enzyme activity were significantly higher after CoQ10 supplementation. In addition, the subjects in the CoQ10 group had significantly higher levels of vitamin E than the placebo group. Levels of the inflammatory markers tumor necrosis factor-alpha and interleukin-6 dropped in the CoQ10 group, indicating a decrease in oxidative stress.

The authors concluded that “Coenzyme Q10 supplementation at 300 mg/d significantly enhances antioxidant enzymes activities and lowers inflammation in patients who have CAD [coronary artery disease] during statins therapy.” They also found that regarding the safety of COQ10 “there were no clinically significant changes in the subjects’ vital signs, serum chemical values, or hematological values, and there were no serious adverse events, no complaints of myalgia or muscle weakness, and no withdrawals due to adverse events. Thus, coenzyme Q10 at a dose of 300 mg/d is safe for co-administration with statins therapy.”

Citation: Bor-Jen Lee, Yu-Fen Tseng, Chi-Hua Yen and Ping-Ting Lin. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutrition Journal 2013, 12:142, 6 November 2013  doi:10.1186/1475-2891-12-142 


Please Discuss This Article:   Post a Comment 

One thing not mentioned
Posted by: moose_29
Nov 17, 2013
Supplementing CoQ10 will hopefully reduce the risk of increased mortality from cancer and degenerative brain disease associated with statin usage. Might be a good idea to supplement Vitamin D as well as it's production (like that of CoQ10) is substantially decreased in those taking statins.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing