Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is the Fibromyalgia Immune System Compromised?

Reduced Dermal Nerve Fiber Diameter in Fibromyalgia

The Neuroinflammation Man: Jarred Younger on Inflammation, Fibromyalgia and Chronic Fatigue Syndrome

Even my tired is tired!

The 50/10 Guide for Fibromyalgia Mobility

Riding the Chronic Illness Roller Coaster

The Next Lyrica? Thousand Person Fibromyalgia Drug Trial Underway

Finding Joy in Every Day

Coenzyme Q10 (CoQ10) for Fibromyalgia, ME/CFS and Migraine

SURVEY RESULTS: What Triggered Your Illness?

 
Print Page
Email Article

The Role of Adaptive and Innate Immune Cells in Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis

  [ 13 votes ]   [ Discuss This Article ]
By Ekua Brenu et al. • www.ProHealth.com • December 28, 2013


By Ekua Brenu et al.

Abstract

Perturbations in immune processes are a hallmark of a number of autoimmune and inflammatory disorders. Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is an inflammatory disorder with possible autoimmune correlates, characterised by reduced Natural Killer (NK) cell activity, elevations in regulatory T cells (Tregs) and dysregulation in cytokine levels.

The purpose of this paper is to examine innate and adaptive immune cell phenotypes and functional characteristics that have not been previously examined in CFS/ME patients.

30 patients with CFS/ME and 25 non-fatigued controls were recruited for this study. Whole blood samples were collected from all participants for the assessment of cell phenotypes, functional properties, receptors, adhesion molecules, antigens and intracellular proteins using flow cytometric protocols.

The cells investigated included NK cells, dendritic cells (DCs), neutrophils, B cells, T cells, gamma delta T cells and Tregs. Significant changes were observed in B cell subsets, Tregs, CD4+CD73+CD39+ T cells, cytotoxic activity, granzyme B, neutrophil antigens, TNF-alpha and IFN-gamma  in the CFS/ME patients in comparison to the non-fatigued controls.

Alterations in B cells, Tregs, NK cells and neutrophils suggest significant impairments in immune regulation in CFS/ME and these may have similarities to a number of autoimmune disorders.

Source: Brenu, Ekua W., Teilah K. Huth, Sharni L. Hardcastle, Kirsty Fuller, Manprit Kaur, Samantha Johnston, Sandra B. Ramos, Don R. Staines, and Sonya M. Marshall-Gradisnik. The Role of Adaptive and Innate Immune Cells in Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis. Int. Immunol. (2013), doi: 10.1093/intimm/dxt068. First published online: December 16, 2013




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing