Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fibromyalgia: The body holding on to past trauma

10 Fast Facts: Fibromyalgia Is Real

Ten Tips to Simplify, Lower the Cost, and Optimize CFS and fibromyalgia Treatment

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

3 Genetic Reset Methods Your Doctor Should Prescribe for Fibromyalgia

How to Obtain Relief for Fibromyalgia - Part 1: Complementary and Alternative Therapies

Keep Learning – Even From Bed!

Top 10 Mood-Boosting Foods for Fibromyalgia

Buying Drugs from Canada - A Good Choice for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?

Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning.

 
Print Page
Email Article

Fibromyalgia Patients Found to Have Low Melatonin Levels

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 2, 2014


Editor's comment: In this study, researchers evaluated the levels of 6-sulphatoxymelatonin (6-SMT) – a major metabolite of melatonin – in the urine of women with fibromyalgia and corresponding healthy controls. They found that the FM patients had significantly lower levels of 6-SMT than the controls as well as worse scores on four health-related assessment tools. Although they were not able to tie the low 6-SMT levels to specific variations in the assessment tools, the researchers hypothesized that low melatonin levels accompanied by other neuroimmunoendocrine changes may have a direct and negative impact on FM symptoms.

The involvement of melatonin in the clinical status of patients with fibromyalgia syndrome.

By A.P. Pernambuco, et al.

Abstract:

OBJECTIVES: The aim of this study was to evaluate the levels of 6-sulphatoxymelatonin (6-SMT) in the urine of patients with fibromyalgia (FM) and correlate them with the score obtained by these patients in four clinical assessment instruments.

METHODS: Fifty-eight women with primary FM and 39 healthy women matched for age and body mass index were included in the study sample. The levels of 6-SMT were evaluated in urine collected from 8 pm until 8 am the next day by the immunosorbent assay. For the clinical evaluation we used the Fibromyalgia Impact Questionnaire (FIQ); Pittsburg Sleep Quality Index (PSQI); Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) and Satisfaction with Life Scale (SWLS). Data normality was assessed using the Kolmogorov-Smirnov test, the differences between groups by means of the Mann-Whitney test and correlation analysis by Spearman's correlation test.

RESULTS: The levels of 6-SMT in the urine of patients with FM were significantly lower than those found in the urine of healthy controls. The score obtained by patients with FM was significantly different from the score achieved by the healthy controls in the four assessment tools. However, no significant correlation between urinary levels of 6-SMT and scores on assessment instruments was observed.

CONCLUSIONS: The results of this study do not discard the involvement of melatonin in the pathophysiology of FM, but may suggest that changes in melatonin levels when associated with other neuroimmunoendocrine changes may impact directly and negatively on the manifestation of symptoms that make up the clinical picture of FM.

Source: Clinical and Experimental Rheumatology, February 24, 2014. By A.P. Pernambuco, L.P. Schetino, R.S. Viana, L.S.Carvalho and D. d'Ávila Reis. Department of Morphology, Federal University of Minas Gerais, Belo Horizonte; Department of Health Sciences, University Centre of Formiga (UNIFOR-MG), Formiga; Department of Health Sciences, University of Itaúna, Itaúna, Brazil.




Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ FibroSleep™ Fibro Freedom™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
"It's Not Easy Being Green" - But It Is Healthy
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map