ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Protecting Your Fibromyalgia Window of Well

Lidocaine Injections Found to Reduce Hypersensitivity to Pain in Fibromyalgia Patients

Autoimmune Research Opening Up New Options for Chronic Pain Sufferers

Is Hyper-parathyroidism Sometimes Misdiagnosed as Fibromyalgia?

Celiac Symptoms in Fibromyalgia Patients

VIDEO: Ribose Helps Fight Fibromyalgia

Fibro-Fog: Are Fibromyalgia Patients Cognitively Impaired?

Prevalence of falls in fibromyalgia patients

SURVEY RESULTS: Patient Experience with Doctors

Melatonin Improves Pain in Fibromyalgia

 
Print Page
Email Article

Fibromyalgia Patients Found to Have Low Melatonin Levels

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 2, 2014


Editor's comment: In this study, researchers evaluated the levels of 6-sulphatoxymelatonin (6-SMT) – a major metabolite of melatonin – in the urine of women with fibromyalgia and corresponding healthy controls. They found that the FM patients had significantly lower levels of 6-SMT than the controls as well as worse scores on four health-related assessment tools. Although they were not able to tie the low 6-SMT levels to specific variations in the assessment tools, the researchers hypothesized that low melatonin levels accompanied by other neuroimmunoendocrine changes may have a direct and negative impact on FM symptoms.

The involvement of melatonin in the clinical status of patients with fibromyalgia syndrome.

By A.P. Pernambuco, et al.

Abstract:

OBJECTIVES: The aim of this study was to evaluate the levels of 6-sulphatoxymelatonin (6-SMT) in the urine of patients with fibromyalgia (FM) and correlate them with the score obtained by these patients in four clinical assessment instruments.

METHODS: Fifty-eight women with primary FM and 39 healthy women matched for age and body mass index were included in the study sample. The levels of 6-SMT were evaluated in urine collected from 8 pm until 8 am the next day by the immunosorbent assay. For the clinical evaluation we used the Fibromyalgia Impact Questionnaire (FIQ); Pittsburg Sleep Quality Index (PSQI); Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) and Satisfaction with Life Scale (SWLS). Data normality was assessed using the Kolmogorov-Smirnov test, the differences between groups by means of the Mann-Whitney test and correlation analysis by Spearman's correlation test.

RESULTS: The levels of 6-SMT in the urine of patients with FM were significantly lower than those found in the urine of healthy controls. The score obtained by patients with FM was significantly different from the score achieved by the healthy controls in the four assessment tools. However, no significant correlation between urinary levels of 6-SMT and scores on assessment instruments was observed.

CONCLUSIONS: The results of this study do not discard the involvement of melatonin in the pathophysiology of FM, but may suggest that changes in melatonin levels when associated with other neuroimmunoendocrine changes may impact directly and negatively on the manifestation of symptoms that make up the clinical picture of FM.

Source: Clinical and Experimental Rheumatology, February 24, 2014. By A.P. Pernambuco, L.P. Schetino, R.S. Viana, L.S.Carvalho and D. d'Ávila Reis. Department of Morphology, Federal University of Minas Gerais, Belo Horizonte; Department of Health Sciences, University Centre of Formiga (UNIFOR-MG), Formiga; Department of Health Sciences, University of Itaúna, Itaúna, Brazil.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Immune Support Supplements

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing