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The percentage of babies and adults with Babesiosis that have low white blood cell counts

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By GP Wormser, et al. • www.ProHealth.com • November 24, 2015


Neutropenia in Congenital and Adult Babesiosis
 
Abstract
 
OBJECTIVES:
Anemia and thrombocytopenia are expected hematologic abnormalities in patients with acute babesiosis, whereas neutropenia (defined as an absolute neutrophil count of ?1,800 neutrophils/?L for adults and <1,200 neutrophils/?L for infants) is not usually considered a feature of this infection. We studied the frequency with which neutropenia occurs in congenital and adult cases of babesiosis.
 
METHODS:
The frequency of neutropenia in cases of congenital babesiosis was determined based on a literature review and on the findings in an unreported case. The frequency of neutropenia in adult patients was assessed based on a review of the medical records of 51 patients who were diagnosed with babesiosis between 2010 and 2013 at two medical centers in the Northeastern United States.
 
RESULTS:
Four (80%; 95% confidence interval [CI], 36%-98%) of five infants with congenital babesiosis whose neutrophil count was reported were neutropenic. Among 51 adult cases with babesiosis, 11 (22%; 95% CI, 12%-35%) were neutropenic on clinical presentation, and seven others developed neutropenia over the next 1 to 21 days. Thus, a total of 18 (35%; 95% CI, 24%-49%) of the adult patients with babesiosis had neutropenia.
 
CONCLUSIONS:
Neutropenia appears to be a common finding in infants with congenital babesiosis and is also observed not infrequently in adults with this infection.

Source: By Wormser GP1, Villafuerte P2, Nolan SM3, Wang G4, Lerner RG5, Saetre KL6, Maria MH6, Branda JA7. Neutropenia in Congenital and Adult Babesiosis. Am J Clin Pathol. 2015 Jul;144(1):94-6. doi: 10.1309/AJCP2PHH4HBVHZFS.




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