ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

You Might Have Fibromyalgia if...

A Link Between Dental Amalgams, Fibromyalgia, ME/CFS and Other Chronic Illnesses

Gait Characteristics of Women with Fibromyalgia: a Premature Aging Pattern

The Pain Brain: Hippocampal Atrophy Found in Fibromyalgia

The Myth of a Perfect Drug for Fibromyalgia or ME/CFS: the NNT Dilemma

VIDEO: Fibromyalgia in Pictures

Your voice matters! New Survey from National Fibromyalgia & Chronic Pain Association (NFMCPA)

Reduced Volume of Hippocampus May Be Related to Cognitive Problems in Fibromyalgia

VIDEO: Fibromyalgia Fitness: Your Simple 5-Step Exercise Plan

Asking for Help Is Giving a Gift

 
Print Page
Email Article

Acetylcholinesterase inhibitors and Gulf War illnesses - Source: Proceedings of the National Academy of Sciences, Mar 10, 2008

  [ 407 votes ]   [ Discuss This Article ]
By Beatrice Golomb, MD, PhD • www.ProHealth.com • March 11, 2008


[Note: acetylcholinesterase inhibitors are used in "nerve agents," pesticides, and a pill (pyridostigmine bromide)that was administered to increase troop survival in case of nerve gas exposure They affect production of the neurotransmitter acetylcholine, and thus signal transmission at the neuromuscular junctions and in the brain.]

Increasing evidence suggests excess illness in Persian Gulf War veterans (GWV) can be explained in part by exposure of GWV to organophosphate and carbamate acetylcholinesterase inhibitors (AChEis), including pyridostigmine bromide (PB), pesticides, and nerve agents.

Evidence germane to the relation of AChEis to illness in GWV was assessed:

  • Many epidemiological studies reported a link between AChEi exposure and chronic symptoms in GWV.
  • The link is buttressed by a dose–response relation of PB pill number to chronic symptoms in GWV.
  • And by a relation between avidity of AChEi clearance and illness, based on genotypes, concentrations, and activity levels of enzymes that detoxify AChEis.

Triangulating evidence derives from studies linking occupational exposure to AChEis to chronic health symptoms that mirror those of ill GWV. Illness is again linked to lower activity of AChEi detoxifying enzymes and genotypes conferring less-avid AChEi detoxification.

AChEi exposure satisfies Hill's presumptive criteria for causality, suggesting this exposure may be causally linked to excess health problems in GWV.

[Note: To read a news story on the study, titled "Health problems in Persian Gulf War veterans higher due to chemical exposure," click here.]

Source: Proceedings of the National Academy of Sciences, March 10, 2008. [E-publication] 10.1073/pnas.0711986105, by Golomb BA, Department of Medicine, University of California, San Diego, California, USA. [E-mail: bgolomb@ucsd.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out
Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing