ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Most Effective Treatment for Fibromyalgia Among Least Used Says Report

ACTION ALERT: Telling Your Chronic Pain Story Now is Important

A NEW Form of Magnesium: Can It Help Brain Fog and Fibromyalgia Pain?

Is Emergency Stress Impacting Your Fibromyalgia Body?

Have Doctors Gone Too Far on Exercise for Fibromyalgia?

Where Is Your Journey Taking You?

Meditation, Cortisol, and Fibromyalgia

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

Dry Needling Plus Physical Therapy: A Major Advance for Fibromyalgia Treatment

Why Fibro Cheaters Prosper

 
Print Page
Email Article

SATB1 reprograms gene expression to promote breast tumor growth and metastasis – Source: Nature, March 13, 2008

  [ 275 votes ]   [ Discuss This Article ]
By Hye-Jung Han, et al. • www.ProHealth.com • March 14, 2008


[See also explanatory editorial: "A protein that makes breast cancer spread"]

Mechanisms underlying global changes in gene expression during tumor progression are poorly understood. SATB1 is a genome organizer that tethers multiple genomic loci and recruits chromatin-remodeling enzymes to regulate chromatin structure and gene expression.

Here we show that SATB1 is expressed by aggressive breast cancer cells and its expression level has high prognostic significance (P < 0.0001), independent of lymph-node status. [Probability that result occurred by chance less than 1 in 10,000.]

RNA-interference-mediated knockdown of SATB1 in highly aggressive (MDA-MB-231) cancer cells altered the expression of >1,000 genes, reversing tumorigenesis by restoring breast-like acinar polarity and inhibiting tumor growth and metastasis in vivo.

Conversely, ectopic SATB1 expression in non-aggressive (SKBR3) cells led to gene expression patterns consistent with aggressive-tumor phenotypes, acquiring metastatic activity in vivo.

SATB1 delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. SATB1 reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis; this is a new mechanism of tumor progression.

Source: Nature, March 13, 2008. 452, 187-193. PMID: 18337816, by Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T. Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley; Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. [E-mail: Terumiks@lbl.gov or YKohwi@lbl.gov]




Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ Energy NADH™ 12.5mg B-12 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Dr Axe Bone Broth Proteins

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes

Natural Remedies

Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map