ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Cannabis Science Fibromyalgia Pain Patch: Fact or Fiction?

Brain Fog

Top 10 Benefits of Laughter for Fibromyalgia

Increased risk of a suicide event in patients with primary fibromyalgia and in fibromyalgia patients...

Beginning Again: Living with the Ups and Downs of Life with Chronic Illness

Chronic Christmas: Surviving the Holidays with a Chronic Illness

The Difference Between Fibromyalgia Tender Points and Myofascial Trigger Points

Are persons with fibromyalgia or other musculoskeletal pain more likely to report hearing loss? A HU...

Medical cannabis - the Canadian perspective.

Productivity Values That Get in the Way of Our Health

 
Print Page
Email Article

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes – Source: Gut, Jul 5, 2012

  [ 6 votes ]   [ Discuss This Article ]
By Patrick A Hughes, et al. • www.ProHealth.com • July 11, 2012


[Note: Though the full text of this article is fee-based, two web-only Data Supplement files - "Materials" and "Methods" - may be accessed here. ]

Objective: The gut is a major site of contact between immune and sensory systems and evidence suggests that patients with irritable bowel syndrome (IBS) have immune dysfunction.

Here we show how this dysfunction differs between major IBS subgroups and how immunocytes communicate with sensory nerves. [Immunocytes are different white blood cell types that participate in the body’s inflammatory & immune responses to protect against infection and repair injured tissues. Unlike red blood cells they have a nucleus.]

Design: Peripheral blood mononuclear cell supernatants [clear fluid at the top of blood sample after centrifuging] from 20 diarrhea predominant IBS (D-IBS) patients, 15 constipation predominant IBS (C-IBS) patients and 36 healthy subjects were applied to mouse colonic sensory nerves, and effects on mechanosensitivity [nerve sensitivity to movement] assessed.

Cytokine/chemokine concentration in the supernatants was assessed by proteomic analysis and correlated with abdominal symptoms, and expression of cytokine receptors evaluated in colonic dorsal root ganglia neurons. We then determined the effects of specific cytokines on colonic afferents.

[Cytokines act as molecular messengers between cells, usually regulating various inflammatory responses. Afferent neurons are nerve pathways that carry impulses from the stimulus receptor site/sense organ through the nervous system toward the brain. Efferent neurons communicate in the opposite direction.]

Results:

• D-IBS supernatants caused mechanical hypersensitivity of mouse colonic afferent endings, which was reduced by infliximab. [Infliximab, aka Remicade, is an antibody that blocks the inflammation-promoting cytokine TNF-alpha and is used to treat (reduce inflammation in) autoimmune diseases such as Crohn’s disease and RA.]

• C-IBS supernatants did not, but occasionally elevated basal discharge [neuron activity].

• Supernatants of healthy subjects inhibited afferent mechanosensitivity via an opioidergic [suppressing perception of pain] mechanism.

Several cytokines were elevated in IBS supernatants, and levels correlated with pain frequency and intensity in patients. Visceral afferents expressed receptors for four cytokines:

• IL-1beta,

• IL-6,

• IL-10 and

• TNF-alpha.

TNF-alpha most effectively caused mechanical hypersensitivity which was blocked by a transient receptor potential channel TRPA1 antagonist. [TRPA1 is one of the many types of ion channels located on cell membranes. It serves as a sensor/communicator. A TRPA1 antagonist would reduce TRPA1 sensitivity.]

IL-1beta elevated basal firing, and this was lost after tetrodotoxin blockade of sodium channels. [IL-1 beta induces pro-inflammatory COX-2 in the central nervous system, contributing to inflammatory pain hypersensitivity. Tetrodotoxin quells neuron activity.]

Conclusions:

Distinct patterns of immune dysfunction and interaction with sensory pathways occur in different patient groups and through different intracellular pathways.

Our results indicate IBS patient subgroups would benefit from selective targeting of the immune system.

Source: Gut, Jul 5, 2012. DOI:10.1136/gutjnl-2011-301856, by Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Isaacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw AL, Brierley SM. Nerve-Gut Research Laboratory, Discipline of Medicine and Discipline of Physiology, Faculty of Health Sciences, The University of Adelaide; Department of Gastroenterology and Hepatology, Royal Adelaide Hospital; and Department of Leukocyte Biology, Women's and Children's Health Research Institute, Women's and Children's Hospital, Adelaide, South Australia, Australia; Department of Bone Marrow Transplantation, University Hospital Essen, West German Cancer Centre, Germany; Neurogastroenterology Group, Blizard Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK. [Email: patrick.hughes@adelaide.edu.au]





Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ Optimized Curcumin Longvida® B-12 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Breaking Through the Mental Fog Breaking Through the Mental Fog
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map